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Literature summary for 2.1.1.299 extracted from

  • Conner, M.M.; Schaner Tooley, C.E.
    Three's a crowd - why did three N-terminal methyltransferases evolve for one job? (2023), J. Cell Sci., 136, jcs260424.
    View publication on PubMed
Search for more literature for 2.1.1.299

Application

Application Comment Organism
medicine high enzyme expression correlates with worse prognosis in colon cancer Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5VVY1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart high expression Homo sapiens
-
skeletal muscle high expression Homo sapiens
-
testis high expression Homo sapiens
-

Subunits

Subunits Comment Organism
monomer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
METTL11B
-
 Homo sapiens
Nalpha-methyltransferase
-
 Homo sapiens
NRMT2
-
 Homo sapiens
NTMT2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme mRNA is upregulated during myogenic and also osteoblastogenic and osteocytic differentiation up

General Information

General Information Comment Organism
malfunction the enzyme is highly mutated in many different cancer types Homo sapiens
physiological function the METTL11A dimer can bind the enzyme monomer, which increases the half-life and methylation activity of METTL11A against non-canonical substrates. The enzyme plays the role of a non-catalytic stabilizing protein for METTL11A Homo sapiens