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Literature summary for 2.1.1.296 extracted from

  • Haussmann, I.U.; Wu, Y.; Nallasivan, M.P.; Archer, N.; Bodi, Z.; Hebenstreit, D.; Waddell, S.; Fray, R.; Soller, M.
    CMTr cap-adjacent 2-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses (2022), Nat. Commun., 13, 1209.
    View publication on PubMed
Search for more literature for 2.1.1.296

Cloned(Commentary)

Cloned (Comment) Organism
expressed in S2 cells Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Drosophila melanogaster 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-(ribonucleotide)-[mRNA] Drosophila melanogaster
-
 S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA]
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Drosophila melanogaster
-
embryo
-
 Drosophila melanogaster
-
nervous system
-
 Drosophila melanogaster
-
ovary
-
 Drosophila melanogaster
-
testis high expression of isoform CMTr2 Drosophila melanogaster
-
trachea high expression of isoform CMTr2 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-(ribonucleotide)-[mRNA]
-
 Drosophila melanogaster S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA]
-
 ?

Synonyms

Synonyms Comment Organism
CMTr cap-adjacent 2'-O-ribose mRNA methyltransferase
-
 Drosophila melanogaster
CMTr1 isoform Drosophila melanogaster
CMTr2 isoform Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Drosophila melanogaster

Expression

Organism Comment Expression
Drosophila melanogaster there are elevated isoform CMTr1 levels during early embryogenesis and a peak of both isoforms CMTr1 and CMTr2 in prepupae up

General Information

General Information Comment Organism
malfunction enzyme-deficient mutant flies are viable and fertile as single and double mutants, exhibiting a slightly reduced survival to adulthood after hatching from the egg, and reduced climbing activity in negative geotaxis assays. In addition, isoform CMTr1 mutants, and to a greater extent isoform CMTr2 mutants, have reduced numbers of synapses at neuromuscular junctions of third instar larvae Drosophila melanogaster
physiological function enzyme-mediated mRNA cap 2'-O-ribose methylation is required for reward learning in Drosophila Drosophila melanogaster