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Literature summary for 2.1.1.292 extracted from

  • Grocholski, T.; Yamada, K.; Sinkkonen, J.; Tirkkonen, H.; Niemi, J.; Metsae-Ketelae, M.
    Evolutionary trajectories for the functional diversification of anthracycline methyltransferases (2019), ACS Chem. Biol., 14, 850-856 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene dnrK, phylogenetic analysis Streptomyces peucetius

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + carminomycin Streptomyces peucetius
-
 S-adenosyl-L-homocysteine + daunorubicin
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces peucetius Q06528
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + carminomycin
-
 Streptomyces peucetius S-adenosyl-L-homocysteine + daunorubicin
-
 ?

Synonyms

Synonyms Comment Organism
4-O-methyltransferase
-
 Streptomyces peucetius
anthracycline methyltransferase
-
 Streptomyces peucetius
DnrK
-
 Streptomyces peucetius

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Streptomyces peucetius

General Information

General Information Comment Organism
evolution phylogenetic analysis of the putative SAM-dependent methyltransferases reveals our distinct clades, which are composed of DnrK and RdmB-type proteins and two other groups of sequences. Evolution of anthracycline methyltransferase-like proteins, the phylogenetic analysis suggests that the functional divergence of these proteins has occurred in situ in their respective gene clusters, overview Streptomyces peucetius
metabolism the S-adenosyl methionine (SAM)-dependent methyltransferase DnrK is a 4-O-methyltransferase involved in daunorubicin biosynthesis Streptomyces peucetius