Cloned (Comment) | Organism |
---|---|
the dauC gene, encoding aklanonic acid methyltransferase, complements dauC-blocked mutants of Streptomyces sp. strain C5, restores in vitro aklanonic acid methyltransferase activities to the mutant strains, and confers in vitro aklanonic acid methyltransferase activity on Streptomyces lividans | Streptomyces sp. |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
24000 | - |
2 * 24000, SDS-PAGE | Streptomyces sp. |
24319 | - |
2 * 24319, SDS-PAGE | Streptomyces sp. |
48000 | - |
gel filtration | Streptomyces sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + aklanonate | Streptomyces sp. | the enzyme is involved in daunomycin biosynthesis | S-adenosyl-L-homocysteine + methyl aklanonate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces sp. | Q55214 | - |
- |
Purification (Comment) | Organism |
---|---|
partial | Streptomyces sp. |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mycelium | - |
Streptomyces sp. | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + aklanonate | - |
Streptomyces sp. | S-adenosyl-L-homocysteine + methyl aklanonate | - |
? | |
S-adenosyl-L-methionine + aklanonate | the enzyme is involved in daunomycin biosynthesis | Streptomyces sp. | S-adenosyl-L-homocysteine + methyl aklanonate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 24000, SDS-PAGE | Streptomyces sp. |
homodimer | 2 * 24319, SDS-PAGE | Streptomyces sp. |
Synonyms | Comment | Organism |
---|---|---|
AAMT | - |
Streptomyces sp. |
aklanonate methyltransferase | - |
Streptomyces sp. |
DauC | - |
Streptomyces sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Streptomyces sp. |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in the biosynthesis of the anthracycline daunorubicin | Streptomyces sp. |