BRENDA - Enzyme Database
show all sequences of 2.1.1.28

Transcriptional silencing of glucocorticoid-inducible phenylethanolamine N-methyltransferase expression by sequential signaling events

Evinger, M.J.; Powers, J.F.; Tischler, A.S.; Exp. Cell Res. 313, 772-781 (2007)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression analysis, transcriptional response of the PNMT gene to GDNF and cpt-cAMP involves distal portions of the PNMT promoter, transient expression of PNMT promoter constructs in MPC 10/9CRC1 cultures
Mus musculus
Engineering
Amino acid exchange
Commentary
Organism
additional information
construction of PNMT promoter constructs using nested deletion constructs treated with DEX or sequentially with GDNF/cAMP/DEX, the suppression of PNMT induction is reversible
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Mus musculus
the phenylethanolamine N-methyltransferase GRE plays a necessary, but not sufficient role in the transcriptional aspects to the control mechanism. Analyses implicate the participation of sequences in the distal 5´promoter of this gene.
?
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Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
; mouse pheochromocytoma cell lines 862L and 10/9CRC1 from tumors arising in separate mice with a heterozygous knockout of the neurofibromatosis gene Nf1
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
10/9CRC1 cell
pheochromocytoma cell line
Mus musculus
-
862L cell
pheochromocytoma cell line
Mus musculus
-
adrenal gland
adrenergic chromaffin cells and medullary tissue
Mus musculus
-
chromaffin cell
phenylethanolamine N-methyltransferase mRNA levels are 30fold increased by dexamethasone. Glial cell line-derived neurotrophic factor and cpt-cAMP each exert negligible influence on baseline phenylethanolamine N-methyltransferase mRNA levels. cAMP effectively blocks dexamethasone induction of phenylethanolamine N-methyltransferase mRNA.
Mus musculus
-
pheochromocytoma cell
pheochromocytomas are tumors of adrenal chromaffin cells. Phenylethanolamine N-methyltransferase mRNA levels are markedly increased by glucocorticoid administration. Dexamethasone elicites approximately 800fold increases in phenylethanolamine N-methyltransferase mRNA levels in mouse pheochromocytoma 862L cells and approximately 75fold increases for mouse pheochromocytoma 10/9CR1 cells. Glial cell line-derived neurotrophic factor and cpt-cAMP alone each produce little or no change in baseline phenylethanolamine N-methyltransferase mRNA levels. In both cell lines, dexamethasone-stimulated increases in phenylethanolamine N-methyltranferase mRNA levels are reduced approximately 90% by prior tratment with cAMP. Glial cell line-derived neurotrophic factor reduces dexamethasone effects on phenylethanolamine N-methyltransferase mRNA levels by 40% in mouse pheochromocytoma 862L cells, while not supressing the dexamethasone response in mouse pheochromocytoma 10/9CRC1 cells. Pretreatment with cAMP and afterwards treatment with glial cell line-derived neurotrophic factor before additon of dexamethasone reduced phenylethanolamine N-methyltransferase expression in mouse pheochromocytoma 862L and 10/9CRC1 cells to 0.1% and 5.5% of their corresponding DEX induced maxima.
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
the phenylethanolamine N-methyltransferase GRE plays a necessary, but not sufficient role in the transcriptional aspects to the control mechanism. Analyses implicate the participation of sequences in the distal 5´promoter of this gene.
673474
Mus musculus
?
-
-
-
-
Cloned(Commentary) (protein specific)
Commentary
Organism
expression analysis, transcriptional response of the PNMT gene to GDNF and cpt-cAMP involves distal portions of the PNMT promoter, transient expression of PNMT promoter constructs in MPC 10/9CRC1 cultures
Mus musculus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
construction of PNMT promoter constructs using nested deletion constructs treated with DEX or sequentially with GDNF/cAMP/DEX, the suppression of PNMT induction is reversible
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Mus musculus
the phenylethanolamine N-methyltransferase GRE plays a necessary, but not sufficient role in the transcriptional aspects to the control mechanism. Analyses implicate the participation of sequences in the distal 5´promoter of this gene.
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
10/9CRC1 cell
pheochromocytoma cell line
Mus musculus
-
862L cell
pheochromocytoma cell line
Mus musculus
-
adrenal gland
adrenergic chromaffin cells and medullary tissue
Mus musculus
-
chromaffin cell
phenylethanolamine N-methyltransferase mRNA levels are 30fold increased by dexamethasone. Glial cell line-derived neurotrophic factor and cpt-cAMP each exert negligible influence on baseline phenylethanolamine N-methyltransferase mRNA levels. cAMP effectively blocks dexamethasone induction of phenylethanolamine N-methyltransferase mRNA.
Mus musculus
-
pheochromocytoma cell
pheochromocytomas are tumors of adrenal chromaffin cells. Phenylethanolamine N-methyltransferase mRNA levels are markedly increased by glucocorticoid administration. Dexamethasone elicites approximately 800fold increases in phenylethanolamine N-methyltransferase mRNA levels in mouse pheochromocytoma 862L cells and approximately 75fold increases for mouse pheochromocytoma 10/9CR1 cells. Glial cell line-derived neurotrophic factor and cpt-cAMP alone each produce little or no change in baseline phenylethanolamine N-methyltransferase mRNA levels. In both cell lines, dexamethasone-stimulated increases in phenylethanolamine N-methyltranferase mRNA levels are reduced approximately 90% by prior tratment with cAMP. Glial cell line-derived neurotrophic factor reduces dexamethasone effects on phenylethanolamine N-methyltransferase mRNA levels by 40% in mouse pheochromocytoma 862L cells, while not supressing the dexamethasone response in mouse pheochromocytoma 10/9CRC1 cells. Pretreatment with cAMP and afterwards treatment with glial cell line-derived neurotrophic factor before additon of dexamethasone reduced phenylethanolamine N-methyltransferase expression in mouse pheochromocytoma 862L and 10/9CRC1 cells to 0.1% and 5.5% of their corresponding DEX induced maxima.
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
the phenylethanolamine N-methyltransferase GRE plays a necessary, but not sufficient role in the transcriptional aspects to the control mechanism. Analyses implicate the participation of sequences in the distal 5´promoter of this gene.
673474
Mus musculus
?
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Other publictions for EC 2.1.1.28
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733076
Qin
Double stable isotope ultra pe ...
Homo sapiens
Anal. Bioanal. Chem.
405
1713-1719
2013
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1
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733211
Wu
Kinetic and pH studies on huma ...
Homo sapiens
Arch. Biochem. Biophys.
539
1-8
2013
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4
6
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3
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3
3
718999
Hou
QM/MM studies on the catalytic ...
Homo sapiens
Biochim. Biophys. Acta
1824
533-541
2012
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1
2
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718693
Grobe
An (R)-specific N-methyltransf ...
Homo sapiens
Arch. Biochem. Biophys.
506
42-47
2011
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1
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1
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1
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1
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718776
Drinkwater
Fragment-based screening by X- ...
Homo sapiens
Biochem. J.
431
51-61
2010
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1
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13
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1
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13
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720467
Kang
Discovery of novel human pheny ...
Homo sapiens
Mol. Cells
29
595-602
2010
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1
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3
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2
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1
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1
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1
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1
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3
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1
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1
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1
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696719
Grunewald
Synthesis of 4,5,6,7-tetrahydr ...
Homo sapiens
Bioorg. Med. Chem.
16
542-559
2008
-
-
-
-
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35
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1
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2
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2
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1
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1
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1
30
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1
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35
30
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1
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2
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1
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1
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697472
Yamano
Association study between rewa ...
Homo sapiens
Compr. Psychiatry
49
503-507
2008
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1
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1
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672557
Grunewald
Exploring the active site of p ...
Homo sapiens, Rattus norvegicus
Bioorg. Med. Chem.
15
1298-1310
2007
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1
1
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26
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3
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2
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5
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2
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2
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12
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1
1
2
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26
12
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3
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5
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2
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2
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673474
Evinger
Transcriptional silencing of g ...
Mus musculus
Exp. Cell Res.
313
772-781
2007
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1
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1
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1
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2
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5
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1
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5
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1
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697358
Bao
Epinephrine is required for no ...
Mus musculus, Mus musculus C57BL/6
Circulation
116
1024-1031
2007
-
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1
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2
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2
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142
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5
1
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1
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5
1
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1
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699423
Gee
-
Enzyme adaptation to inhibitor ...
Homo sapiens
J. Med. Chem.
50
6441
2007
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1
1
1
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11
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1
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1
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1
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1
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1
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1
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1
19
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1
1
1
1
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11
19
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1
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1
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1
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1
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1
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673009
Kvetnansky
Gene expression of phenylethan ...
Mus musculus, Rattus norvegicus
Cell. Mol. Neurobiol.
26
735-754
2006
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6
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675297
Grunewald
Application of the Goldilocks ...
Homo sapiens
J. Med. Chem.
49
2939-2952
2006
-
1
1
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16
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2
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15
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675306
Grunewald
Comparison of the binding of 3 ...
Homo sapiens
J. Med. Chem.
49
5424-5433
2006
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1
1
1
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9
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8
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661326
Grunewald
Exploring the active site of p ...
Homo sapiens
Bioorg. Med. Chem.
13
1261-1273
2005
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1
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33
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1
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672011
Gee
Mode of binding of methyl acce ...
Homo sapiens
Biochemistry
44
16875-16885
2005
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1
1
5
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1
14
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2
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8
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5
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14
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3
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8
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672345
Gee
Disulfide-linked dimers of hum ...
Homo sapiens
Biochim. Biophys. Acta
1750
82-92
2005
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1
1
3
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2
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3
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2
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1
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1
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1
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1
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3
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1
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1
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1
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672573
Grunewald
Exploring the active site of p ...
Homo sapiens
Bioorg. Med. Chem. Lett.
15
1143-1147
2005
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1
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4
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1
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4
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1
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4
4
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672582
Grunewald
Inhibitors of phenylethanolami ...
Homo sapiens
Bioorg. Med. Chem. Lett.
15
5319-5323
2005
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1
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1
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672987
Cleary
Expression of the noradrenalin ...
Homo sapiens, Rattus norvegicus
Cell Tissue Res.
322
443-453
2005
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639433
Pohorecky
Purification and properties of ...
Bos taurus, Rattus norvegicus
Arch. Biochem. Biophys.
156
703-711
1973
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-
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10
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-
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-
-
-
2
-
-
1
-
-
2
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
-
1
-
2
1
-
-
-
-
-
1
-
1
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639431
Connett
Purification and properties of ...
Bos taurus
J. Biol. Chem.
245
329-334
1970
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1
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1
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2
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1
1
-
1
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1
-
-
-
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
1
-
-
1
-
-
-
3
-
1
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639430
Axelrod
Purification and properties of ...
Bos taurus, Cavia porcellus, Felis catus, Macaca mulatta, Oryctolagus cuniculus, Rattus norvegicus
J. Biol. Chem.
237
1657-1660
1962
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3
1
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6
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1
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9
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1
19
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2
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-
-
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3
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1
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-
-
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1
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9
-
1
19
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2
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