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Literature summary for 2.1.1.28 extracted from

  • McMillan, F.M.; Archbold, J.; McLeish, M.J.; Caine, J.M.; Criscione, K.R.; Grunewald, G.L.; Martin, J.L.
    Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (2004), J. Med. Chem., 47, 37-44.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with S-adenosyl-L-homocysteien and either 7-iodo-1,2,3,4-tetrahydroisoquinoline or 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine or 7-sulfonamido-1,2,3,4-tetrahydroisoquinoline Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
7-iodo-1,2,3,4-tetrahydroisoquinoline
-
Homo sapiens
7-sulfonamido-1,2,3,4-tetrahydroisoquinoline
-
Homo sapiens
8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.047
-
4-aminomethyl-1,2,3,4-tetrahydroisoquinoline
-
Homo sapiens
0.07
-
phenylethanolamine
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P11086
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 4-aminomethyl-1,2,3,4-tetrahydroisoquinoline
-
Homo sapiens S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + phenylethanolamine
-
Homo sapiens S-adenosyl-L-homocysteine + N-methylphenylethanolamine
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00026
-
8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine
-
Homo sapiens
0.00037
-
7-iodo-1,2,3,4-tetrahydroisoquinoline
-
Homo sapiens
0.00056
-
7-sulfonamido-1,2,3,4-tetrahydroisoquinoline
-
Homo sapiens