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Literature summary for 2.1.1.28 extracted from

  • Fuller, R.W.
    Norepinephrine N-methyltransferase from rabbit adrenal glands (1987), Methods Enzymol., 142, 655-660.
    View publication on PubMed
Search for more literature for 2.1.1.28

Inhibitors

Inhibitors Comment Organism Structure
2-chlorophenylethanolamine
-
 Oryctolagus cuniculus
2-fluorophenylethanolamine
-
 Oryctolagus cuniculus
3,4-Dichlorophenylethanolamine
-
 Oryctolagus cuniculus
3,4-dihydroxyphenylethanolamine
-
 Oryctolagus cuniculus
3-bromophenylethanolamine
-
 Oryctolagus cuniculus
4-bromophenylethanolamine
-
 Oryctolagus cuniculus
4-fluorophenylethanolamine
-
 Oryctolagus cuniculus
4-hydroxyphenylethanolamine
-
 Oryctolagus cuniculus
epinephrine
-
 Oryctolagus cuniculus
S-adenosylhomocysteine
-
 Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0008
-
 3,4-Dichlorophenylethanolamine
-
 Oryctolagus cuniculus
0.0024
-
 3-chloro-4-hydroxyphenylethanolamine
-
 Oryctolagus cuniculus
0.013
-
 3,4-dihydroxyphenylethanolamine
-
 Oryctolagus cuniculus
0.017
-
 4-hydroxyphenylethanolamine
-
 Oryctolagus cuniculus
0.077
-
 phenylethanolamine
-
 Oryctolagus cuniculus
0.089
-
 3-hydroxyphenylethanolamine
-
 Oryctolagus cuniculus
0.366
-
 3-methoxy-4-hydroxy-phenylethanolamine
-
 Oryctolagus cuniculus
0.676
-
 2-hydroxyphenylethanolamine
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Oryctolagus cuniculus terminal enzyme in the biosynthetic pathway for epinephrine ?
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxyphenylethanolamine + S-adenosyl-L-methionine i.e. o-octopamine Oryctolagus cuniculus ? + S-adenosyl-L-homocysteine
-
 ?
3,4-dichlorophenyl ethanolamine + S-adenosyl-L-methionine
-
 Oryctolagus cuniculus ? + S-adenosyl-L-homocysteine
-
 ?
3,4-dichlorophenylethanolamine + S-adenosyl-L-methionine
-
 Oryctolagus cuniculus N-methyl-3,4-dichlorophenylethanolamine + S-adenosyl-L-homocysteine
-
 ?
3-chloro-4-hydroxyphenylethanolamine + S-adenosyl-L-methionine
-
 Oryctolagus cuniculus ? + S-adenosyl-L-homocysteine
-
 ?
3-hydroxyphenylethanolamine + S-adenosyl-L-methionine i.e. m-octopamine Oryctolagus cuniculus N-methyl-m-octopamine + S-adenosyl-L-homocysteine
-
 ?
4-hydroxyphenylethanolamine + S-adenosyl-L-methionine i.e. octopamine Oryctolagus cuniculus ? + S-adenosyl-L-homocysteine
-
 ?
additional information terminal enzyme in the biosynthetic pathway for epinephrine Oryctolagus cuniculus ?
-
 ?
norepinephrine + S-adenosyl-L-methionine
-
 Oryctolagus cuniculus epinephrine + S-adenosyl-L-homocysteine
-
 ?
normetanephrine + S-adenosyl-L-methionine i.e. 3-methoxy-4-hydroxyphenylethanolamine Oryctolagus cuniculus metanephrine + S-adenosyl-L-homocysteine
-
 ?
phenylethanolamine + S-adenosyl-L-methionine
-
 Oryctolagus cuniculus N-methylphenylethanolamine + S-adenosyl-L-homocysteine
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.054
-
 epinephrine
-
 Oryctolagus cuniculus