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Literature summary for 2.1.1.255 extracted from

  • Komatsu, M.; Tsuda, M.; Omura, S.; Oikawa. H.; Ikeda, H.
    Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol (2008), Proc. Natl. Acad. Sci. USA, 105, 7422-7427.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.255

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, genetic organization, phylogenetic analysis and tree, expression in Escherichia coli Saccharopolyspora erythraea
DNA and amino acid sequence determination and analysis, genetic organization, phylogenetic analysis and tree, expression in Escherichia coli Streptomyces ambofaciens
DNA and amino acid sequence determination and analysis, genetic organization, phylogenetic analysis and tree, expression in Escherichia coli Streptomyces lasalocidi
DNA and amino acid sequence determination and analysis, genetic organization, phylogenetic analysis and tree, expression in Escherichia coli Micromonospora olivasterospora
expression in Escherichia coli Saccharopolyspora erythraea
expression in Escherichia coli Streptomyces ambofaciens
expression in Escherichia coli Streptomyces lasalocidi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + geranyl diphosphate Saccharopolyspora erythraea
-
 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate Streptomyces ambofaciens
-
 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate Streptomyces lasalocidi
-
 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate Micromonospora olivasterospora
-
 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate Saccharopolyspora erythraea the enzyme is involved in the biosynthesis of the terpenoid alcohol 2-methylisoborneol S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate Streptomyces ambofaciens the enzyme is involved in the biosynthesis of the terpenoid alcohol 2-methylisoborneol S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate Streptomyces lasalocidi the enzyme is involved in the biosynthesis of the terpenoid alcohol 2-methylisoborneol S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate Streptomyces lasalocidi NRRL2382R
-
 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate Streptomyces lasalocidi NRRL2382R the enzyme is involved in the biosynthesis of the terpenoid alcohol 2-methylisoborneol S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate Micromonospora olivasterospora KY11048
-
 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate Saccharopolyspora erythraea NRRL 2338
-
 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate Saccharopolyspora erythraea NRRL 2338 the enzyme is involved in the biosynthesis of the terpenoid alcohol 2-methylisoborneol S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate Streptomyces ambofaciens ISP5053
-
 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate Streptomyces ambofaciens ISP5053 the enzyme is involved in the biosynthesis of the terpenoid alcohol 2-methylisoborneol S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Micromonospora olivasterospora F5HSX5
-
-
Micromonospora olivasterospora KY11048 F5HSX5
-
-
Saccharopolyspora erythraea A4FG18
-
-
Saccharopolyspora erythraea NRRL 2338 A4FG18
-
-
Streptomyces ambofaciens A3KI18
-
-
Streptomyces ambofaciens ISP5053 A3KI18
-
-
Streptomyces lasalocidi D3KYU3
-
-
Streptomyces lasalocidi NRRL2382R D3KYU3
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + geranyl diphosphate = S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate biosynthetic mechanism, overview Saccharopolyspora erythraea
a
S-adenosyl-L-methionine + geranyl diphosphate = S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate biosynthetic mechanism, overview Streptomyces ambofaciens
a
S-adenosyl-L-methionine + geranyl diphosphate = S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate biosynthetic mechanism, overview Streptomyces lasalocidi
a
S-adenosyl-L-methionine + geranyl diphosphate = S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate biosynthetic mechanism, overview Micromonospora olivasterospora
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + geranyl diphosphate
-
 Saccharopolyspora erythraea S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Streptomyces ambofaciens S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Streptomyces lasalocidi S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Micromonospora olivasterospora S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Saccharopolyspora erythraea S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate GC-MS analysis of products ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Streptomyces ambofaciens S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate GC-MS analysis of products ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Streptomyces lasalocidi S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate GC-MS analysis of products ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Micromonospora olivasterospora S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate GC-MS analysis of products ?
S-adenosyl-L-methionine + geranyl diphosphate the enzyme is involved in the biosynthesis of the terpenoid alcohol 2-methylisoborneol Saccharopolyspora erythraea S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate the enzyme is involved in the biosynthesis of the terpenoid alcohol 2-methylisoborneol Streptomyces ambofaciens S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate the enzyme is involved in the biosynthesis of the terpenoid alcohol 2-methylisoborneol Streptomyces lasalocidi S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Streptomyces lasalocidi NRRL2382R S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Streptomyces lasalocidi NRRL2382R S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate GC-MS analysis of products ?
S-adenosyl-L-methionine + geranyl diphosphate the enzyme is involved in the biosynthesis of the terpenoid alcohol 2-methylisoborneol Streptomyces lasalocidi NRRL2382R S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Micromonospora olivasterospora KY11048 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Micromonospora olivasterospora KY11048 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate GC-MS analysis of products ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Saccharopolyspora erythraea NRRL 2338 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Saccharopolyspora erythraea NRRL 2338 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate GC-MS analysis of products ?
S-adenosyl-L-methionine + geranyl diphosphate the enzyme is involved in the biosynthesis of the terpenoid alcohol 2-methylisoborneol Saccharopolyspora erythraea NRRL 2338 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Streptomyces ambofaciens ISP5053 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?
S-adenosyl-L-methionine + geranyl diphosphate
-
 Streptomyces ambofaciens ISP5053 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate GC-MS analysis of products ?
S-adenosyl-L-methionine + geranyl diphosphate the enzyme is involved in the biosynthesis of the terpenoid alcohol 2-methylisoborneol Streptomyces ambofaciens ISP5053 S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
GPP methyltransferase
-
 Saccharopolyspora erythraea
GPP methyltransferase
-
 Streptomyces ambofaciens
GPP methyltransferase
-
 Streptomyces lasalocidi

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Saccharopolyspora erythraea
S-adenosyl-L-methionine
-
 Streptomyces ambofaciens
S-adenosyl-L-methionine
-
 Streptomyces lasalocidi
S-adenosyl-L-methionine
-
 Micromonospora olivasterospora

General Information

General Information Comment Organism
metabolism the enzyme is important in the biosynthesis of 2-methylisoborneol, which involves the methylation of geranyl diphosphate by GPP methyltransferase and its subsequent cyclization by monoterpene cyclase to 2-methylisoborneol Saccharopolyspora erythraea
metabolism the enzyme is important in the biosynthesis of 2-methylisoborneol, which involves the methylation of geranyl diphosphate by GPP methyltransferase and its subsequent cyclization by monoterpene cyclase to 2-methylisoborneol Streptomyces ambofaciens
metabolism the enzyme is important in the biosynthesis of 2-methylisoborneol, which involves the methylation of geranyl diphosphate by GPP methyltransferase and its subsequent cyclization by monoterpene cyclase to 2-methylisoborneol Streptomyces lasalocidi
metabolism the enzyme is important in the biosynthesis of 2-methylisoborneol, which involves the methylation of geranyl diphosphate by GPP methyltransferase and its subsequent cyclization by monoterpene cyclase to 2-methylisoborneol Micromonospora olivasterospora