Cloned (Comment) | Organism |
---|---|
gene mtmB1and mtmB2C2, operon encoding MMA methylamine methyltransferase, quantitative RT-PCR expression analysis, comparison with other methylamine methyltransferases, overview. Transcriptional regulation of genes encoding methylamine methyltransferases in cells growing on Ttrimethyamine or methanol in the presence of ammonium, overview | Methanosarcina mazei |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
methylamine + a [Co(I) methylamine-specific corrinoid protein] | Methanosarcina mazei | - |
a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia | - |
? | |
methylamine + a [Co(I) methylamine-specific corrinoid protein] | Methanosarcina mazei Goe1 | - |
a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methanosarcina mazei | - |
DSM 3647, genes mtmB1C1 and mtmB2C2 | - |
Methanosarcina mazei Goe1 | - |
DSM 3647, genes mtmB1C1 and mtmB2C2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
methylamine + a [Co(I) methylamine-specific corrinoid protein] | - |
Methanosarcina mazei | a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia | - |
? | |
methylamine + a [Co(I) methylamine-specific corrinoid protein] | - |
Methanosarcina mazei Goe1 | a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mtmB1 | - |
Methanosarcina mazei |
Organism | Comment | Expression |
---|---|---|
Methanosarcina mazei | transcription of the mtmB1C1 operon is not affected by the nitrogen source but appears to be increased when trimethylamine is the sole carbon and energy source. Under nitrogen limitation, a 543fold up-regulation of the mtmB2C2 operon encoding MMA methyltransferase 2 is obtained when methanol was used as carbon source, whereas transcription of the homologous mtmB1C1 operon occurs at a constant level independently of the nitrogen source | up |
General Information | Comment | Organism |
---|---|---|
metabolism | when growing on trimethylamine, nitrogen fixation does not occur in the cells, indicating that ammonium released during trimethylamine degradation is sufficient to serve as a nitrogen source and represses nif gene induction, transcriptional regulation of soluble methyltransferases, which catalyze the initial step of methylamine consumption by methanogenesis, in response to different carbon and nitrogen sources, overview. Regulation of soluble methyltransferases in response to different nitrogen and carbon sources, overview | Methanosarcina mazei |