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Literature summary for 2.1.1.244 extracted from

  • Dong, C.; Dong, G.; Li, L.; Zhu, L.; Tempel, W.; Liu, Y.; Huang, R.; Min, J.
    An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2 (2018), Commun. Biol., 1, 183 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.244

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + N-terminal-PPKRIA-[RCC1] Homo sapiens
-
 3 S-adenosyl-L-homocysteine + N-terminal-trimethyl-PPKRIA-[RCC1]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BV86
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + CPKRIA mono- and dimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
2 S-adenosyl-L-methionine + FPKRIA dimethylation and low level trimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
2 S-adenosyl-L-methionine + HPKRIA dimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
2 S-adenosyl-L-methionine + IPKRIA mono- and dimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
2 S-adenosyl-L-methionine + KPKRIA dimethylation and low level trimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
2 S-adenosyl-L-methionine + LPKRIA dimethylation and low level trimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
2 S-adenosyl-L-methionine + MPKRIA dimethylation and low level trimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
2 S-adenosyl-L-methionine + NPKRIA dimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
2 S-adenosyl-L-methionine + PPKRIA dimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
2 S-adenosyl-L-methionine + QPKRIA dimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
2 S-adenosyl-L-methionine + RPKRIA dimethylation and low level trimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
2 S-adenosyl-L-methionine + TPKRIA mono- and dimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
2 S-adenosyl-L-methionine + VPKRIA mono- and dimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
2 S-adenosyl-L-methionine + WPKRIA mono- and dimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
2 S-adenosyl-L-methionine + YPKRIA dimethylation by NTMT1 Homo sapiens 2 S-adenosyl-L-homocysteine + ?
-
 ?
3 S-adenosyl-L-methionine + APKRIA trimethylation by NTMT1 Homo sapiens 3 S-adenosyl-L-homocysteine + ?
-
 ?
3 S-adenosyl-L-methionine + GPKRIA trimethylation by NTMT1 Homo sapiens 3 S-adenosyl-L-homocysteine + ?
-
 ?
3 S-adenosyl-L-methionine + N-terminal-PPKRIA-[RCC1]
-
 Homo sapiens 3 S-adenosyl-L-homocysteine + N-terminal-trimethyl-PPKRIA-[RCC1]
-
 ?
3 S-adenosyl-L-methionine + N-terminal-[RCC1]
-
 Homo sapiens 3 S-adenosyl-L-homocysteine + ?
-
 ?
3 S-adenosyl-L-methionine + SPKRIA trimethylation by NTMT1 Homo sapiens 3 S-adenosyl-L-homocysteine + ?
-
 ?
additional information NTMT1 is a tri-methyltransferase Homo sapiens ?
-
-
S-adenosyl-L-methionine + DPKRIA monomethylation by NTMT1 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + EPKRIA monomethylation by NTMT1 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?

Synonyms

Synonyms Comment Organism
alpha-N-terminal methyltransferase 1
-
 Homo sapiens
N-terminal methyltransferase
-
 Homo sapiens
NTMT1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine dependent on Homo sapiens

General Information

General Information Comment Organism
evolution structural comparison of isozymes NTMT1 and NTMT2 (EC 2.1.1.299), overview. NTMT1 and NTMT2 employ a similar substrate recognition mode Homo sapiens
malfunction knockdown of NTMT1 results in hypersensitivity of breast cancer cell lines to doublestranded DNA breaks (DSBs) and increased proliferation of estrogen receptor positive breast cancer cells MCF-7 and LCC9 Homo sapiens
additional information substrate and ligand binding structures of NTMT1 and NTMT2 (EC 2.1.1.299), overview Homo sapiens
physiological function protein lysine/arginine methylation, the addition of a methyl group at the free alpha-N-termini of proteins represents a unique mode of post-translational modification. NTMT1 is an S-adenosyl-L-methionine (SAM)-dependent methyltransferase. During the enzymatic reaction, NTMT1 transfers a methyl group from SAM to the alpha-amino group of the protein substrates, resulting in the production of S-adenosyl-L-homocysteine (SAH) and alpha-N-methylated proteins. NTMT1 recognizes proteins bearing an N-terminal X-P-K/R consensus sequence, including RCC1, RB1, DDB2, CENP-A/B, PARP3, etc. Homo sapiens