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Literature summary for 2.1.1.233 extracted from

  • Dudiki, T.; Kadunganattil, S.; Ferrara, J.; Kline, D.; Vijayaraghavan, S.
    Changes in carboxy methylation and tyrosine phosphorylation of protein phosphatase PP2A are associated with epididymal sperm maturation and motility (2015), PLoS ONE, 10, e0141961 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.233

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine Mus musculus
-
 S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
-
 ?
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine Bos taurus
-
 S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus Q3T0H0
-
-
Mus musculus A0A0U1RNF2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
additional information immunohistochemic enzyme detection in tissues Mus musculus
-
additional information immunohistochemic enzyme detection in tissues Bos taurus
-
semen isolated from proximal caput, distal caput, and caudal regions of the epididymis Mus musculus
-
semen isolated from proximal caput, distal caput, and caudal regions of the epididymis Bos taurus
-
spermatozoon
-
 Mus musculus
-
spermatozoon
-
 Bos taurus
-
testis
-
 Mus musculus
-
testis
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine
-
 Mus musculus S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
-
 ?
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine
-
 Bos taurus S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
-
 ?

Synonyms

Synonyms Comment Organism
LCMT-1
-
 Mus musculus
LCMT-1
-
 Bos taurus
LCMT1
-
 Mus musculus
LCMT1
-
 Bos taurus
leucine carboxyl methyltransferase 1
-
 Mus musculus
leucine carboxyl methyltransferase 1
-
 Bos taurus
PP2A-methyltransferase
-
 Mus musculus
PP2A-methyltransferase
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Mus musculus
S-adenosyl-L-methionine
-
 Bos taurus

General Information

General Information Comment Organism
metabolism in vivo demethylation of sperm PP2A in the epididymis, regulation of protein phosphatase activity in sperm Mus musculus
metabolism in vivo demethylation of sperm PP2A in the epididymis, regulation of protein phosphatase activity in sperm Bos taurus
physiological function the enzyme PP2A methyl transferase, LCMT1 responsible for transferring the methyl group from S-adenosyl methionine specifically to PP2A Mus musculus
physiological function the enzyme PP2A methyl transferase, LCMT1 responsible for transferring the methyl group from S-adenosyl methionine specifically to PP2A Bos taurus