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Literature summary for 2.1.1.233 extracted from

  • Park, H.J.; Lee, K.W.; Oh, S.; Yan, R.; Zhang, J.; Beach, T.G.; Adler, C.H.; Voronkov, M.; Braithwaite, S.P.; Stock, J.B.; Mouradian, M.M.
    Protein phosphatase 2A and its methylation modulating enzymes LCMT-1 and PME-1 are dysregulated in tauopathies of progressive supranuclear palsy and Alzheimer disease (2018), J. Neuropathol. Exp. Neurol., 77, 139-148 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine Homo sapiens
-
 S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UIC8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain immunohistochemic analysis of LCMT-1 content in human postmortem brain sections, brain from humans with disease, such as progressive supranuclear palsy and Alzheimer's disease, clinical and neuropathological characteristics, overview Homo sapiens
-
frontal lobe
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine
-
 Homo sapiens S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
-
 ?

Synonyms

Synonyms Comment Organism
LCMT-1
-
 Homo sapiens
leucine carboxyl methyltransferase
-
 Homo sapiens
PPMT
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction Protein phosphatase 2A and its methylation modulating enzymes LCMT-1 and PME-1 are dysregulated in tauopathies of progressive supranuclear palsy and Alzheimer's disease, pathologic phenotype, overview. Analyses shows a decrease of methyl-PP2A and an increase of demethyl-PP2A with a concomitant reduction in the methyl/demethyl PP2A ratio in both PSP (74%) and AD (76%) brains. This is associated with a decrease in LCMT-1 and an increase in the demethylating enzyme, protein phosphatase methylesterase (PME-1), in both diseases. State of PP2A regulation in tauopathies, overview Homo sapiens