Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine | Mus musculus | LCMT-1 is the major methyltransferase in embryonic fibroblasts for all three PP2A subfamily phosphatases, PP2Ac, PP4c, and PP6c | S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester | - |
? | |
S-adenosyl-L-methionine + [protein phosphatase 4 catalytic subunit]-leucine | Mus musculus | LCMT-1 is the major methyltransferase in embryonic fibroblasts for all three PP2A subfamily phosphatases, PP2Ac, PP4c, and PP6c | S-adenosyl-L-homocysteine + [protein phosphatase 4 catalytic subunit]-leucine methyl ester | - |
? | |
S-adenosyl-L-methionine + [protein phosphatase 6 catalytic subunit]-leucine | Mus musculus | LCMT-1 is the major methyltransferase in embryonic fibroblasts for all three PP2A subfamily phosphatases, PP2Ac, PP4c, and PP6c | S-adenosyl-L-homocysteine + [protein phosphatase 6 catalytic subunit]-leucine methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | A2RTH5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | embryonic | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine | - |
Mus musculus | S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester | - |
? | |
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine | LCMT-1 is the major methyltransferase in embryonic fibroblasts for all three PP2A subfamily phosphatases, PP2Ac, PP4c, and PP6c | Mus musculus | S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester | - |
? | |
S-adenosyl-L-methionine + [protein phosphatase 4 catalytic subunit]-leucine | - |
Mus musculus | S-adenosyl-L-homocysteine + [protein phosphatase 4 catalytic subunit]-leucine methyl ester | - |
? | |
S-adenosyl-L-methionine + [protein phosphatase 4 catalytic subunit]-leucine | LCMT-1 is the major methyltransferase in embryonic fibroblasts for all three PP2A subfamily phosphatases, PP2Ac, PP4c, and PP6c | Mus musculus | S-adenosyl-L-homocysteine + [protein phosphatase 4 catalytic subunit]-leucine methyl ester | - |
? | |
S-adenosyl-L-methionine + [protein phosphatase 6 catalytic subunit]-leucine | - |
Mus musculus | S-adenosyl-L-homocysteine + [protein phosphatase 6 catalytic subunit]-leucine methyl ester | - |
? | |
S-adenosyl-L-methionine + [protein phosphatase 6 catalytic subunit]-leucine | LCMT-1 is the major methyltransferase in embryonic fibroblasts for all three PP2A subfamily phosphatases, PP2Ac, PP4c, and PP6c | Mus musculus | S-adenosyl-L-homocysteine + [protein phosphatase 6 catalytic subunit]-leucine methyl ester | - |
? |
General Information | Comment | Organism |
---|---|---|
malfunction | mouse embryonic fibroblasts derived from LCMT-1 knock-out mouse embryos have reduced levels of PP2A B regulatory subunit and PP4R1 relative to control mouse embryonic fibroblasts, indicating that LCMT-1 is important for maintaining normal levels of these subunits. LCMT-1 homozygous knock-out mouse embryonic fibroblasts exhibit hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex | Mus musculus |
physiological function | the enzyme coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function | Mus musculus |