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Literature summary for 2.1.1.233 extracted from

  • Tian, H.; Lu, Y.; Liu, J.; Liu, W.; Lu, L.; Duan, C.; Gao, G.; Yang, H.
    Leucine carboxyl methyltransferase downregulation and protein phosphatase methylesterase upregulation contribute toward the inhibition of protein phosphatase 2A by alpha-synuclein (2018), Front. Aging Neurosci., 10, 173 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.233

Inhibitors

Inhibitors Comment Organism Structure
alpha-synuclein alpha-syn, negatively regulates protein phosphatase 2A (PP2A) methylation via LCMT-1 and PME-1, whilst activation of LCMT-1 and inhibition of PME-1 reverses this process Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine Mus musculus
-
 S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
-
 ?
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine Mus musculus C57BL/6N
-
 S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus A0A0U1RNF2
-
-
Mus musculus C57BL/6N A0A0U1RNF2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
 Mus musculus
-
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine
-
 Mus musculus S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
-
 ?
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine
-
 Mus musculus C57BL/6N S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
-
 ?

Synonyms

Synonyms Comment Organism
LCMT-1
-
 Mus musculus
leucine carboxyl methyltransferase
-
 Mus musculus
PME-1
-
 Mus musculus
PP2A methyltransferase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus alpha-syn overexpression results in PP2A demethylation. This demethylation is mediated via downregulated leucine carboxyl methyltransferase (LCMT-1) expression down

General Information

General Information Comment Organism
malfunction alpha-synuclein (alpha-syn) overexpression induces increased alpha-syn phosphorylation at Ser129, and protein phosphatase 2A (PP2A) inhibition, in vitro and in vivo. alpha-Syn overexpression results in PP2A demethylation. This demethylation is mediated via downregulated leucine carboxyl methyltransferase (LCMT-1) expression, and upregulated protein phosphatase methylesterase (PME-1, EC 3.1.1.89) expression. Furthermore, LCMT-1 overexpression, or PME-1 inhibition, reverses alpha-syn-induced increases in alpha-syn phosphorylation and apoptosis Mus musculus
physiological function LCMT-1 overexpression or protein phosphatase methylesterase (PME-1, EC 3.1.1.89) inhibition protects against alpha-syn-induced protein phosphatase 2A (PP2A) inhibition, and increases in apoptosis of SK-N-SH cells Mus musculus