Cloned (Comment) | Organism |
---|---|
gene clbA, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in Escherichia coli strain AS19 using plasmid pLJ10 | Bacillus amyloliquefaciens |
gene clbB, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in Escherichia coli strain AS19 using plasmid pLJ10 | Brevibacillus brevis |
gene clbC, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in Escherichia coli strain AS19 using plasmid pLJ10 | Alkalihalobacillus clausii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | Bacillus amyloliquefaciens | - |
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | - |
? | |
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | Brevibacillus brevis | - |
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | - |
? | |
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | Alkalihalobacillus clausii | - |
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | - |
? | |
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | Bacillus amyloliquefaciens FZB42 | - |
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | - |
? | |
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | Brevibacillus brevis NBRC 100599 | - |
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Alkalihalobacillus clausii | Q5WJ42 | or strain domuvar, gene clbC, a cfr-like gene | - |
Bacillus amyloliquefaciens | - |
gene clbA, a cfr-like gene | - |
Bacillus amyloliquefaciens FZB42 | - |
gene clbA, a cfr-like gene | - |
Brevibacillus brevis | C0ZJA6 | gene clbB, a cfr-like gene | - |
Brevibacillus brevis NBRC 100599 | C0ZJA6 | gene clbB, a cfr-like gene | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | - |
Bacillus amyloliquefaciens | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | - |
? | |
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | - |
Brevibacillus brevis | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | - |
? | |
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | - |
Alkalihalobacillus clausii | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | - |
? | |
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | - |
Bacillus amyloliquefaciens | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | verification of RNA methylation at A2503 in 23S rRNA by primer extension method | ? | |
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | - |
Brevibacillus brevis | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | verification of RNA methylation at A2503 in 23S rRNA by primer extension method | ? | |
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | - |
Alkalihalobacillus clausii | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | verification of RNA methylation at A2503 in 23S rRNA by primer extension method | ? | |
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | - |
Bacillus amyloliquefaciens FZB42 | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | - |
? | |
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | - |
Bacillus amyloliquefaciens FZB42 | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | verification of RNA methylation at A2503 in 23S rRNA by primer extension method | ? | |
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | - |
Brevibacillus brevis NBRC 100599 | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | - |
? | |
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | - |
Brevibacillus brevis NBRC 100599 | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | verification of RNA methylation at A2503 in 23S rRNA by primer extension method | ? |
Synonyms | Comment | Organism |
---|---|---|
ClbA | - |
Bacillus amyloliquefaciens |
ClbB | - |
Brevibacillus brevis |
ClbC | - |
Alkalihalobacillus clausii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Bacillus amyloliquefaciens | |
S-adenosyl-L-methionine | - |
Brevibacillus brevis | |
S-adenosyl-L-methionine | - |
Alkalihalobacillus clausii |
General Information | Comment | Organism |
---|---|---|
evolution | ClbA acts via the same mechanism as the Cfr methyltransferase | Bacillus amyloliquefaciens |
evolution | ClbB acts via the same mechanism as the Cfr methyltransferase | Brevibacillus brevis |
evolution | ClbC acts via the same mechanism as the Cfr methyltransferase | Alkalihalobacillus clausii |
physiological function | ClbA confers resistance to antibiotics, florfenicol, clindamycin, linezolid, tiamulin, and streptogramin A/streptogramin B, to the cell, also when expressed in Escherichia coli strain AS19, overview | Bacillus amyloliquefaciens |
physiological function | ClbB confers resistance to antibiotics, florfenicol, clindamycin, linezolid, tiamulin, and streptogramin A/streptogramin B, to the cell, also when expressed in Escherichia coli strain AS19, overview | Brevibacillus brevis |
physiological function | ClbC confers resistance to antibiotics, florfenicol, clindamycin, linezolid, tiamulin, and streptogramin A/streptogramin B, to the cell, also when expressed in Escherichia coli strain AS19, overview | Alkalihalobacillus clausii |