Literature summary for 2.1.1.224 extracted from

Locke, J.B.; Rahawi, S.; Lamarre, J.; Mankin, A.S.; Shaw, K.J.
Genetic environment and stability of cfr in methicillin-resistant Staphylococcus aureus CM05 (2012), Antimicrob. Agents Chemother., 56, 332-340.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene cfr, while cfr is typically plasmid borne, in CM05 it is located on the chromosome and is coexpressed with ermB as part of the mlr operon. DNA and amino acid sequence determination and analysis and genetic organization, overview. The cfr-containing mlr operon is located within a 15.5-kb plasmid-like insertion into 23S rRNA allele 4. In the LZDs colonies, designated CM05DELTA, a recombination event involving the two ermB genes had occurred, resulting in the deletion of cfr and the 3= flanking region, cfr-istAS-istBS-ermB	Staphylococcus aureus

Cloned (Comment)

Organism

gene cfr, while cfr is typically plasmid borne, in CM05 it is located on the chromosome and is coexpressed with ermB as part of the mlr operon. DNA and amino acid sequence determination and analysis and genetic organization, overview. The cfr-containing mlr operon is located within a 15.5-kb plasmid-like insertion into 23S rRNA allele 4. In the LZDs colonies, designated CM05DELTA, a recombination event involving the two ermB genes had occurred, resulting in the deletion of cfr and the 3= flanking region, cfr-istAS-istBS-ermB

Staphylococcus aureus

Protein Variants

Protein Variants	Comment	Organism
additional information	insertion of the cfr region into the CM05 chromosome occurs at a beta/six site I recognition site. Identification of a subpopulation of cfr-negative CM05, CM05DELTA, arising from recombination between duplicate ermB regions, overview	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	E1VCY5	gene cfr, while cfr is typically plasmid borne, in CM05 it is located on the chromosome and is coexpressed with ermB as part of the mlr operon	-
Staphylococcus aureus CM05	E1VCY5	gene cfr, while cfr is typically plasmid borne, in CM05 it is located on the chromosome and is coexpressed with ermB as part of the mlr operon	-

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Release 2023.1 (January 2023)