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Literature summary for 2.1.1.222 extracted from

  • Jonassen, T.; Clarke, C.F.
    Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis (2000), J. Biol. Chem., 275, 12381-12387.
    View publication on PubMed
Search for more literature for 2.1.1.222

Cloned(Commentary)

Cloned (Comment) Organism
when expressed in multicopy, the human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40998
-
 x * 40998, calculated from sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in biosynthesis of ubiquinone-10 in human and catalyzes the methylation of 3-demethylubiquinol-10 to ubiquinol-10 (EC 2.1.1.64) and the methylation of 3,4-dihydroxy-5-decaprenylbenzoate to 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate (EC 2.1.1.114) ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NZJ6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in biosynthesis of ubiquinone-10 in human and catalyzes the methylation of 3-demethylubiquinol-10 to ubiquinol-10 (EC 2.1.1.64) and the methylation of 3,4-dihydroxy-5-decaprenylbenzoate to 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate (EC 2.1.1.114) Homo sapiens ?
-
 ?
additional information wide substrate specificity. The enzyme methylates both eukaryotic substrates demethylubiquinol-3 (this activity is classified as EC 2.1.1.64) and 3,4-dihydroxy-5-farnesylbenzoic acid (this activity is classified as EC 2.1.1.114) and the distinct prokaryotic substrate 3-((2E,6E)-farnesyl)benzene-1,2-diol Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol. The substrate is an artificial farnesylated analog of the Escherichia coli substrate 2-all-trans-octaprenyl-6-hydroxyphenol, an intermediate in the biosynthesis of ubiquinone-8 in Escherichia coli Homo sapiens S-adenosyl-L-homocysteine + 2-methoxy-6-((2E,6E)-farnesyl)phenol i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol ?

Subunits

Subunits Comment Organism
? x * 40998, calculated from sequence Homo sapiens