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Literature summary for 2.1.1.217 extracted from
- m1A Post-transcriptional modification in tRNAs (2017), Biomolecules, 7, 20 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + adenine22 in tRNA | Streptococcus pneumoniae | - |
S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA | - |
? |  |
| S-adenosyl-L-methionine + adenine22 in tRNA | Vibrio cholerae | - |
S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA | - |
? | |
| S-adenosyl-L-methionine + adenine22 in tRNA | Listeria monocytogenes serotype 4b | - |
S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA | - |
? | |
| S-adenosyl-L-methionine + adenine22 in tRNA | Staphylococcus aureus | - |
S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA | - |
? | |
| S-adenosyl-L-methionine + adenine22 in tRNA | Listeria monocytogenes serotype 4b LL195 | - |
S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Listeria monocytogenes serotype 4b | A0A0E1R6X8 | - |
- |
| Listeria monocytogenes serotype 4b LL195 | A0A0E1R6X8 | - |
- |
| Staphylococcus aureus | A0A0D6HIR7 | - |
- |
| Streptococcus pneumoniae | - |
- |
- |
| Vibrio cholerae | A0A0H6U323 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + adenine22 in tRNA | - |
Streptococcus pneumoniae | S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA | - |
? | |
| S-adenosyl-L-methionine + adenine22 in tRNA | - |
Vibrio cholerae | S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA | - |
? | |
| S-adenosyl-L-methionine + adenine22 in tRNA | - |
Listeria monocytogenes serotype 4b | S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA | - |
? | |
| S-adenosyl-L-methionine + adenine22 in tRNA | - |
Staphylococcus aureus | S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA | - |
? | |
| S-adenosyl-L-methionine + adenine22 in tRNA | - |
Listeria monocytogenes serotype 4b LL195 | S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| m1A22 MTase | - |
Streptococcus pneumoniae |
| m1A22 MTase | - |
Vibrio cholerae |
| m1A22 MTase | - |
Listeria monocytogenes serotype 4b |
| m1A22 MTase | - |
Staphylococcus aureus |
| TrmK | - |
Streptococcus pneumoniae |
| TrmK | - |
Vibrio cholerae |
| TrmK | - |
Listeria monocytogenes serotype 4b |
| TrmK | - |
Staphylococcus aureus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| S-adenosyl-L-methionine | - |
Streptococcus pneumoniae | |
| S-adenosyl-L-methionine | - |
Vibrio cholerae | |
| S-adenosyl-L-methionine | - |
Listeria monocytogenes serotype 4b | |
| S-adenosyl-L-methionine | - |
Staphylococcus aureus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | the m1A22 MTase (TrmK) belongs to the COG2384 protein family, RFM/class I, and has orthologues in Gram-positive and Gram-negative bacteria, with no homologues identified in eukaryotes to date. TrmK is well conserved in the bacterial kingdom with enzymes from a number of pathogenic bacteria, e.g. Vibrio cholerae, Listeria monocytogenes, Staphylococcus aureus, Streptococcus pneumoniae, showing a high sequence identity (>40%). The m1A22 modification has been identified only in tRNAs from bacteria | Streptococcus pneumoniae |
| evolution | the m1A22 MTase (TrmK) belongs to the COG2384 protein family, RFM/class I, and has orthologues in Gram-positive and Gram-negative bacteria, with no homologues identified in eukaryotes to date. TrmK is well conserved in the bacterial kingdom with enzymes from a number of pathogenic bacteria, e.g. Vibrio cholerae, Listeria monocytogenes, Staphylococcus aureus, Streptococcus pneumoniae, showing a high sequence identity (>40%). The m1A22 modification has been identified only in tRNAs from bacteria | Vibrio cholerae |
| evolution | the m1A22 MTase (TrmK) belongs to the COG2384 protein family, RFM/class I, and has orthologues in Gram-positive and Gram-negative bacteria, with no homologues identified in eukaryotes to date. TrmK is well conserved in the bacterial kingdom with enzymes from a number of pathogenic bacteria, e.g. Vibrio cholerae, Listeria monocytogenes, Staphylococcus aureus, Streptococcus pneumoniae, showing a high sequence identity (>40%). The m1A22 modification has been identified only in tRNAs from bacteria | Listeria monocytogenes serotype 4b |
| evolution | the m1A22 MTase (TrmK) belongs to the COG2384 protein family, RFM/class I, and has orthologues in Gram-positive and Gram-negative bacteria, with no homologues identified in eukaryotes to date. TrmK is well conserved in the bacterial kingdom with enzymes from a number of pathogenic bacteria, e.g. Vibrio cholerae, Listeria monocytogenes, Staphylococcus aureus, Streptococcus pneumoniae, showing a high sequence identity (>40%). The m1A22 modification has been identified only in tRNAs from bacteria | Staphylococcus aureus |
| metabolism | the methylation on the N1 atom of adenosine to form 1-methyladenosine (m1A) has been identified at nucleotide position 9, 14, 22, 57, and 58 in different tRNAs. In some cases, these modifications have been shown to increase tRNA structural stability and induce correct tRNA folding | Streptococcus pneumoniae |
| metabolism | the methylation on the N1 atom of adenosine to form 1-methyladenosine (m1A) has been identified at nucleotide position 9, 14, 22, 57, and 58 in different tRNAs. In some cases, these modifications have been shown to increase tRNA structural stability and induce correct tRNA folding | Vibrio cholerae |
| metabolism | the methylation on the N1 atom of adenosine to form 1-methyladenosine (m1A) has been identified at nucleotide position 9, 14, 22, 57, and 58 in different tRNAs. In some cases, these modifications have been shown to increase tRNA structural stability and induce correct tRNA folding | Listeria monocytogenes serotype 4b |
| metabolism | the methylation on the N1 atom of adenosine to form 1-methyladenosine (m1A) has been identified at nucleotide position 9, 14, 22, 57, and 58 in different tRNAs. In some cases, these modifications have been shown to increase tRNA structural stability and induce correct tRNA folding | Staphylococcus aureus |
| physiological function | the enzyme is essential for the bacterial survival | Streptococcus pneumoniae |
| physiological function | the enzyme is essential for the bacterial survival | Vibrio cholerae |
| physiological function | the enzyme is essential for the bacterial survival | Listeria monocytogenes serotype 4b |
| physiological function | the enzyme is essential for the bacterial survival | Staphylococcus aureus |
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