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Literature summary for 2.1.1.204 extracted from

  • Uysal, F.; Akkoyunlu, G.; Ozturk, S.
    DNA methyltransferases exhibit dynamic expression during spermatogenesis (2016), Reprod. Biomed. Online, 33, 690-702 .
    View publication on PubMed
Search for more literature for 2.1.1.204

Protein Variants

Protein Variants Comment Organism
additional information generation of Dnmt2 knockout mice Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + cytosine38 in tRNAAsp Mus musculus
-
 S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp
-
 ?
S-adenosyl-L-methionine + cytosine38 in tRNAAsp Homo sapiens
-
 S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14717
-
-
Mus musculus O55055
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information expression of DNMTs in spermatogenetic cells in humans, enzyme DNMT2 is not involved, in contrast to the other DNMTs, overview Homo sapiens
-
additional information expression of DNMTs in spermatogenetic cells in mice, enzyme DNMT2 is not involved, in contrast to the other DNMTs, overview Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information DNMT2 is able to methylate the cytosine 38 in the anticodon loop of aspartic acid transfer RNA instead of transferring methyl groups to the cytosine residues in the genomic DNA Mus musculus ?
-
-
additional information DNMT2 is able to methylate the cytosine 38 in the anticodon loop of aspartic acid transfer RNA instead of transferring methyl groups to the cytosine residues in the genomic DNA Homo sapiens ?
-
-
S-adenosyl-L-methionine + cytosine38 in tRNAAsp
-
 Mus musculus S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp
-
 ?
S-adenosyl-L-methionine + cytosine38 in tRNAAsp
-
 Homo sapiens S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp
-
 ?

Synonyms

Synonyms Comment Organism
DNA methyltransferase 2
-
 Mus musculus
DNA methyltransferase 2
-
 Homo sapiens
Dnmt2
-
 Mus musculus
Dnmt2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Mus musculus
S-adenosyl-L-methionine
-
 Homo sapiens

General Information

General Information Comment Organism
evolution the DNMTs encompass three different structural regions: N-terminal regulatory domain, C-terminal catalytic domain and a central linker region. The N-terminal regulatory domain is particularly implicated in determining subcellular localization of the DNMT and in allocating unmethylated DNA strands from hemi-methylated ones. The C-terminal catalytic domain consists of 10 different characteristic motifs, and six of them (I, IV, VI, VIII, IX and X) are evolutionally conserved among mammals. General structure of mammalian DNA methyltransferases (DNMTs), overview. DNMT2 shows structural and functional differences when compared with the other DNMTs, it does not include N-terminal domain, and therefore cannot contribute to de-novo or maintenance methylation process Mus musculus
evolution the DNMTs encompass three different structural regions: N-terminal regulatory domain, C-terminal catalytic domain and a central linker region. The N-terminal regulatory domain is particularly implicated in determining subcellular localization of the DNMT and in allocating unmethylated DNA strands from hemi-methylated ones. The C-terminal catalytic domain consists of 10 different characteristic motifs, and six of them (I, IV, VI, VIII, IX and X) are evolutionally conserved among mammals. General structure of mammalian DNA methyltransferases (DNMTs), overview. DNMT2 shows structural and functional differences when compared with the other DNMTs, it does not include N-terminal domain, and therefore cannot contribute to de-novo or maintenance methylation process Homo sapiens
malfunction Dnmt2 knockout mice (Dnmt2-/-) exhibit disruption in the RNA methyltransferase activity Mus musculus
physiological function enzyme DNMT2 carries out methylation of the cytosine 38 in the anticodon loop of aspartic acid transfer RNA. It is not involved in spermatogenesis Mus musculus
physiological function enzyme DNMT2 carries out methylation of the cytosine 38 in the anticodon loop of aspartic acid transfer RNA. It is not involved in spermatogenesis Homo sapiens