Literature summary for 2.1.1.20 extracted from

Wang, Y.; Wu, M.; Lin, Y.; Tang, F.; Ko, H.; Chiang, E.
Regulation of folate-mediated one-carbon metabolism by glycine N-methyltransferase (GNMT) and methylenetetrahydrofolate reductase (MTHFR) (2015), J. Nutr. Sci. Vitaminol., 61, S148-S150 .

Search for more literature for 2.1.1.20

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9QXF8	-	-

Synonyms

Synonyms	Comment	Organism
GNMT	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	GNMT affects transmethylation kinetics and S-adenosylmethionine synthesis, and facilitates the conservation of methyl groups by limiting homocysteine remethylation fluxes. Restoring GNMT assists methylfolate-dependent reactions and ameliorates the consequences of folate depletion. GNMT expression in vivo improves folate retention and bioavailability in the liver. Loss of GNMT impairs nucleotide biosynthesis. Over-expression of GNMT enhances nucleotide biosynthesis and improves DNA integrity by reducing uracil misincorporation in DNA both in vitro and in vivo	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)