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Literature summary for 2.1.1.20 extracted from

  • Yen, C.H.; Lu, Y.C.; Li, C.H.; Lee, C.M.; Chen, C.Y.; Cheng, M.Y.; Huang, S.F.; Chen, K.F.; Cheng, A.L.; Liao, L.Y.; Lee, Y.H.; Chen, Y.M.
    Functional characterization of glycine N-methyltransferase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma (2012), Mol. Med., 18, 286-296.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
full-length human GNMT is used as the bait in a yeast two-hybrid screen system with a human kidney cDNA library Homo sapiens

Protein Variants

Protein Variants Comment Organism
DELTA171-295 to map the interactive domain of GNMT plasmids containing different domains GNMT are constructed: The C-terminal 171-295 amino acid fragment of GNMT is identified as interactive domain Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens a mammalian target of rapamycin (mTOR) inhibitor (DEP domain containing MTOR-interacting protein [DEPDC6/DEPTOR]) is identified as a GNMT-binding protein by using yeast two-hybrid screening. The C-terminal half of GNMT interacts with the PSD-95/Dlg1/ZO-1 (PDZ) domain of DEPDC6/DEPTOR ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
kidney kidney cDNA library is used Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information a mammalian target of rapamycin (mTOR) inhibitor (DEP domain containing MTOR-interacting protein [DEPDC6/DEPTOR]) is identified as a GNMT-binding protein by using yeast two-hybrid screening. The C-terminal half of GNMT interacts with the PSD-95/Dlg1/ZO-1 (PDZ) domain of DEPDC6/DEPTOR Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
glycine N-methyltransferase
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Homo sapiens
GNMT
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Homo sapiens

General Information

General Information Comment Organism
malfunction overexpression of GNMT causes activation of mTOR/raptor downstream signaling and delays G2/M cell cycle progression, which altogether results in cellular senescence Homo sapiens
physiological function GNMT regulates hepatocellular growth in part through interacting with DEPDC6/DEPTOR and modulating mTOR/raptor signaling pathway Homo sapiens