BRENDA - Enzyme Database
show all sequences of 2.1.1.20

Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma

Huang, Y.C.; Chen, M.; Shyr, Y.M.; Su, C.H.; Chen, C.K.; Li, A.F.; Ho, D.M.; Chen, Y.M.; J. Gastroenterol. Hepatol. 23, 1384-1389 (2008)

Data extracted from this reference:

Application
Application
Commentary
Organism
diagnostics
enzyme level suitable as prognostic marker for human cholangiocarcinoma and hepatocellular carcinoma
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
concentrated in the paranuclear region near the bile duct lumen
Homo sapiens
5737
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
major folate binding protein
?
-
-
-
S-adenosyl-L-methionine + glycine
Homo sapiens
key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine
S-adenosyl-L-homocysteine + N-methylglycine
N-methylglycine = sarcosine
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
cholangiocarcinoma patients
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
bile duct
high expression in normal tissue, reduced expression in tumorous tissue, some tumor samples show no enzyme expression
Homo sapiens
-
cholangiocyte
-
Homo sapiens
-
liver
high expression in normal tissue, only 4% of hepatocellular carcinoma show GNMT expression
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
major folate binding protein
688121
Homo sapiens
?
-
-
-
-
S-adenosyl-L-methionine + glycine
key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine
688121
Homo sapiens
S-adenosyl-L-homocysteine + N-methylglycine
N-methylglycine = sarcosine
-
-
?
Application (protein specific)
Application
Commentary
Organism
diagnostics
enzyme level suitable as prognostic marker for human cholangiocarcinoma and hepatocellular carcinoma
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
concentrated in the paranuclear region near the bile duct lumen
Homo sapiens
5737
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
major folate binding protein
?
-
-
-
S-adenosyl-L-methionine + glycine
Homo sapiens
key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine
S-adenosyl-L-homocysteine + N-methylglycine
N-methylglycine = sarcosine
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
bile duct
high expression in normal tissue, reduced expression in tumorous tissue, some tumor samples show no enzyme expression
Homo sapiens
-
cholangiocyte
-
Homo sapiens
-
liver
high expression in normal tissue, only 4% of hepatocellular carcinoma show GNMT expression
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
major folate binding protein
688121
Homo sapiens
?
-
-
-
-
S-adenosyl-L-methionine + glycine
key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine
688121
Homo sapiens
S-adenosyl-L-homocysteine + N-methylglycine
N-methylglycine = sarcosine
-
-
?
Other publictions for EC 2.1.1.20
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
734396
Chou
Role of glycine N-methyltransf ...
Mus musculus
J. Gastroenterol. Hepatol.
29
494-501
2014
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1
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734702
Li
Role of glycine N-methyltransf ...
Mus musculus
Mol. Med.
20
684-696
2014
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734506
Ottaviani
Characterisation of the androg ...
Homo sapiens
J. Mol. Endocrinol.
51
301-312
2013
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1
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1
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735096
DebRoy
A novel tumor suppressor funct ...
Homo sapiens
PLoS ONE
8
e70062
2013
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720481
Yen
Functional characterization of ...
Homo sapiens
Mol. Med.
18
286-296
2012
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1
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1
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1
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4
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1
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1
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2
2
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-
733385
Luka
Differences in folate-protein ...
Rattus norvegicus
Biochim. Biophys. Acta
1824
286-291
2012
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1
1
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1
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720299
Wang
Glycine-N methyltransferase ex ...
Homo sapiens
J. Nutr.
141
777-782
2011
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2
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1
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1
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1
1
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720403
Song
The important role of glycine ...
Homo sapiens
Mod. Pathol.
24
1272-1280
2011
-
1
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2
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1
1
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699962
Fang
Benzo(a)pyrene induced glycine ...
Fundulus heteroclitus
Mar. Environ. Res.
69S1
S74-S76
2010
-
-
1
-
-
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-
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3
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1
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-
703849
Lee
Characterization of the 5 regu ...
Homo sapiens
Gene
443
151-157
2009
-
1
-
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1
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2
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4
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4
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1
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1
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1
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704068
Liao
Characterization of a glycine ...
Mus musculus
Int. J. Cancer
124
816-826
2009
-
1
-
-
-
-
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-
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4
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3
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1
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3
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1
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1
1
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-
704524
Luka
Glycine N-methyltransferase an ...
Danio rerio, Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
J. Biol. Chem.
284
22507-22511
2009
12
-
1
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6
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12
-
12
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7
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36
-
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6
6
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6
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2
12
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1
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2
6
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12
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12
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36
-
-
6
6
-
-
-
-
6
-
-
-
6
12
12
6
-
-
706826
Yen
Glycine N-methyltransferase af ...
Homo sapiens
Toxicol. Appl. Pharmacol.
235
296-304
2009
-
-
1
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1
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4
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1
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1
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1
1
-
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-
685388
Luka
Acetylation of N-terminal vali ...
Rattus norvegicus
Biochim. Biophys. Acta
1784
1342-1346
2008
-
-
1
-
-
-
2
2
-
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1
2
-
1
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1
1
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-
1
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3
-
1
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2
1
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1
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2
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2
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1
2
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1
1
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1
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3
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1
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2
1
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-
687008
Martinez-Chantar
Loss of the glycine N-methyltr ...
Mus musculus
Hepatology
47
1191-1199
2008
-
-
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1
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2
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3
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3
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1
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3
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2
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687011
Liu
-
Glycine N-methyltransferase -/ ...
Mus musculus
Hepatology
47
768-769
2008
-
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1
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2
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1
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4
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2
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1
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4
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2
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688121
Huang
Glycine N-methyltransferase is ...
Homo sapiens
J. Gastroenterol. Hepatol.
23
1384-1389
2008
-
1
-
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1
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2
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2
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3
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2
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1
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1
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3
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-
706903
Luka
Methyltetrahydrofolate in fola ...
Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Vitam. Horm.
79
325-345
2008
-
-
5
1
3
-
10
-
10
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10
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8
-
4
5
-
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17
-
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6
5
-
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1
2
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5
-
1
3
-
2
10
-
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10
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10
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4
5
-
17
-
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6
5
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1
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673122
Huang
Haplotypes, loss of heterozygo ...
Homo sapiens
Clin. Cancer Res.
13
1412-1420
2007
-
2
1
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2
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2
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8
-
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2
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2
1
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2
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8
-
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2
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674879
Luka
5-methyltetrahydrofolate is bo ...
Rattus norvegicus
J. Biol. Chem.
282
4069-4075
2007
-
-
1
1
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2
-
1
-
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3
-
3
-
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1
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3
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3
1
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1
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1
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2
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1
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3
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1
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3
-
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3
1
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-
689908
Luka
Destabilization of human glyci ...
Homo sapiens
Protein Sci.
16
1957-1964
2007
-
-
1
1
1
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-
-
-
-
-
2
1
3
-
-
1
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-
-
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3
1
1
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1
-
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1
-
1
1
-
-
-
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-
-
-
-
2
1
-
-
1
-
-
-
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
671233
Nieman
Folate status modulates the in ...
Rattus norvegicus
Am. J. Physiol. Endocrinol. Metab.
291
E1235-E1242
2006
-
1
-
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1
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2
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2
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1
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1
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2
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1
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677022
Luka
Identification of phosphorylat ...
Rattus norvegicus
Protein Sci.
15
785-794
2006
1
1
1
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-
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1
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3
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1
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3
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1
1
1
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1
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1
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3
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677194
Lee
Benzo[a]pyrene and glycine N-m ...
Homo sapiens
Toxicol. Appl. Pharmacol.
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126-135
2006
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677223
Luka
A glycine N-methyltransferase ...
Homo sapiens, Mus musculus
Transgenic Res.
15
393-397
2006
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675559
Beagle
The glycine N-methyltransferas ...
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J. Nutr.
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2005
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657792
Kloor
Characterization of glycine N- ...
Oryctolagus cuniculus
Biochem. Cell Biol.
82
369-374
2004
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1
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658385
Chen
Glycine N-methyltransferase tu ...
Homo sapiens
Cancer Res.
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2004
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660475
Pakhomova
Glycine N-methyltransferases: ...
Homo sapiens, Mus musculus
Proteins
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331-337
2004
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2
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657660
Luka
Human glycine N-methyltransfer ...
Homo sapiens
Arch. Biochem. Biophys.
420
153-160
2003
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657755
Luka
Effect of naturally occurring ...
Homo sapiens
Biochem. Biophys. Res. Commun.
312
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2003
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1
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6
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658007
Takata
Catalytic mechanism of glycine ...
Rattus norvegicus
Biochemistry
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8394-8402
2003
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5
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12
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10
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659768
Rowling
Retinoic acid and glucocortico ...
Rattus norvegicus
J. Nutr.
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3392-3398
2003
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5
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659769
Ozias
All-trans-retinoic acid rapidl ...
Rattus norvegicus
J. Nutr.
133
4090-4094
2003
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1
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-
660421
Luka
Expression and purification of ...
Homo sapiens, Mus musculus, Rattus norvegicus
Protein Expr. Purif.
28
280-286
2003
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3
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7
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3
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3
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1
3
3
3
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-
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485227
Luka
Mutations in human glycine N-m ...
Homo sapiens
Hum. Genet.
110
68-74
2002
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1
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1
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485228
Rowling
Vitamin A and its derivatives ...
Rattus norvegicus
J. Nutr.
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365-369
2002
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485229
Rowling
Hepatic glycine N-methyltransf ...
Rattus norvegicus
J. Nutr.
132
2545-2550
2002
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485232
McMullen
Activation and induction of gl ...
Rattus norvegicus
Arch. Biochem. Biophys.
401
73-80
2002
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485221
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Mechanisms for auto-inhibition ...
Rattus norvegicus
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298
149-162
2000
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485219
Pattanayek
Crystal structure of apo-glyci ...
Rattus norvegicus
Protein Sci.
7
1326-1331
1998
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1
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485226
Ogawa
Structure, function and physio ...
Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Int. J. Biochem. Cell Biol.
30
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1998
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485222
Bhat
Glycine N-methyltransferase is ...
Rattus norvegicus
J. Biol. Chem.
272
21221-21226
1997
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485223
Bhat
The homodimeric form of glycin ...
Rattus norvegicus
Biochemistry
36
9906-9910
1997
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485224
Ogawa
Rat liver 4 S-benzo[a]pyrene-b ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
233
300-304
1997
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2
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485230
Aida
Mouse glycine N-methyltransfer ...
Mus musculus
Horm. Metab. Res.
29
646-649
1997
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1
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485220
Fu
Crystal structure of glycine N ...
Rattus norvegicus
Biochemistry
35
11985-11993
1996
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485225
Raha
Rat liver cytosolic 4 S polycy ...
Rattus norvegicus
J. Biol. Chem.
269
5750-5756
1994
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485231
Yeo
Tissue distribution of glycine ...
Rattus norvegicus
Proc. Natl. Acad. Sci. USA
91
210-214
1994
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485216
Yeo
Purification and properties of ...
Rattus norvegicus
J. Biol. Chem.
267
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485213
Wagner
Phosphorylation modulates the ...
Rattus norvegicus
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264
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485217
Fujioka
Function and reactivity of sul ...
Rattus norvegicus
Biochemistry
26
5696-5702
1987
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2
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485215
Fujioka
Reaction of rat liver glycine ...
Rattus norvegicus
J. Biol. Chem.
261
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1986
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485218
Wagner
Inhibition of glycine N-methyl ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
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746-752
1985
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485214
Ogawa
Purification and properties of ...
Rattus norvegicus
J. Biol. Chem.
257
3447-3452
1982
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485212
Heady
Purification and characterizat ...
Oryctolagus cuniculus
J. Biol. Chem.
248
69-72
1973
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