Literature summary for 2.1.1.20 extracted from

Chen, S.Y.; Lin, J.R.; Darbha, R.; Lin, P.; Liu, T.Y.; Chen, Y.M.
Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway (2004), Cancer Res., 64, 3617-3623.

Search for more literature for 2.1.1.20

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	GNMT is expressed in cytoplasm before treatment with benzo(a)pyrene and translocated to cell nuclei after treatment with benzo(a)pyrene	Homo sapiens	5737	-
nucleus	GNMT is expressed in cytoplasm before treatment with benzo(a)pyrene and translocated to cell nuclei after treatment with benzo(a)pyrene	Homo sapiens	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	interaction of benzo(a)pyrene with the enzyme may contribute to carcinogenesis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
HA22T/VGH cell	-	Homo sapiens	-
Hep-G2 cell	-	Homo sapiens	-
Huh-7 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	interaction of benzo(a)pyrene with the enzyme may contribute to carcinogenesis	Homo sapiens	?	-	?
S-adenosyl-L-methionine + glycine	-	Homo sapiens	S-adenosyl-L-homocysteine + sarcosine	-	?

Synonyms

Synonyms	Comment	Organism
GNMT	-	Homo sapiens

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Release 2023.1 (January 2023)