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Literature summary for 2.1.1.20 extracted from
- Characterization of glycine N-methyltransferase from rabbit liver (2004), Biochem. Cell Biol., 82, 369-374.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2'-deoxyadenosine | - |
Oryctolagus cuniculus |  |
| 3-deazaadenosine | - |
Oryctolagus cuniculus | |
| 5'-N-ethylcarboxamidoadenosine | - |
Oryctolagus cuniculus | |
| 5'-S-isobutylthio-5'-deoxyadenosine | - |
Oryctolagus cuniculus | |
| aciclovir | - |
Oryctolagus cuniculus | |
| adenosine | - |
Oryctolagus cuniculus | |
| AMP | - |
Oryctolagus cuniculus | |
| Gly | at very high concentrations | Oryctolagus cuniculus | |
| S-adenosyl-L-homocysteine | - |
Oryctolagus cuniculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2 | - |
S-adenosyl-L-methionine | pH 8.6 | Oryctolagus cuniculus | |
| 1 | - |
Gly | pH 8.6 | Oryctolagus cuniculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 130000 | - |
gel filtration | Oryctolagus cuniculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.5 | - |
- |
Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + glycine | - |
Oryctolagus cuniculus | S-adenosyl-L-homocysteine + sarcosine | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.6 | - |
- |
Oryctolagus cuniculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 9.5 | pH 7.5: about 40% of maximal activity, pH 9.5: about 45% of maximal activity | Oryctolagus cuniculus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
S-adenosyl-L-homocysteine | pH 8.6 | Oryctolagus cuniculus | |
| 0.056 | - |
5'-S-isobutylthio-5'-deoxyadenosine | pH 8.6 | Oryctolagus cuniculus | |
| 0.21 | - |
adenosine | pH 8.6 | Oryctolagus cuniculus | |
| 0.28 | - |
aciclovir | pH 8.6 | Oryctolagus cuniculus | |
| 0.38 | - |
2'-deoxyadenosine | pH 8.6 | Oryctolagus cuniculus | |
| 0.51 | - |
5'-N-ethylcarboxamidoadenosine | pH 8.6 | Oryctolagus cuniculus | |
| 0.9 | - |
3-deazaadenosine | pH 8.6 | Oryctolagus cuniculus | |
| 4.5 | - |
AMP | pH 8.6 | Oryctolagus cuniculus | |
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Release 2023.1 (January 2023)
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