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Literature summary for 2.1.1.20 extracted from
- Human glycine N-methyltransferase is unfolded by urea through a compact monomer state (2003), Arch. Biochem. Biophys., 420, 153-160.
General Stability
| General Stability | Organism |
|---|---|
| urea unfolding of GNMT is a two-step process. The first transition is a reversible dissociation of the GNMT tetramer to compact monomers in 1.0-3.5 M urea with enzyme inactivation. The second step of GNMT unfolding is a reversible transition of monomers from compact to a fully unfolded state with R(S) of 50 A, exposed tryptophan residues, and disrupted secondary structure in 8 M urea | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Urea | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
recombinant enzyme | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + glycine | - |
Homo sapiens | S-adenosyl-L-homocysteine + sarcosine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GNMT | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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