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Literature summary for 2.1.1.2 extracted from
- p53 and Metabolism: The GAMT connection (2009), Mol. Cell, 36, 351-352.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + guanidinoacetate | - |
Mus musculus | S-adenosyl-L-homocysteine + creatine | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GAMT | - |
Mus musculus |
| guanidinoacetate methyltransferase | - |
Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | both RNA and protein levels of GAMT are increased in a p53-dependent manner after various inducers of genotoxic stress (etoposide, H2O2, and gamma-irradiation), glucose deprivation induces GAMT in a p53-dependent manner, GAMT mRNA and protein are increased in several tissues of glucose-deprived p53 wild-type mice while remaining unchanged in the same tissues of p53 null mice | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | loss of GAMT causes a creatine deficiency syndrome that is characterized by neurological and motor dysfunction as well as developmental delay/regression, mental retardation, and related defects | Mus musculus |
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