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Literature summary for 2.1.1.2 extracted from

  • Brosnan, J.T.; Wijekoon, E.P.; Warford-Woolgar, L.; Trottier, N.L.; Brosnan, M.E.; Brunton, J.A.; Bertolo, R.F.
    Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance (2009), J. Nutr., 139, 1292-1297.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-
Sus scrofa
-
7 to 8-d-old piglets, milk from lactating sows
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Sus scrofa
-
blood plasma
-
Sus scrofa
-
brain
-
Sus scrofa
-
brain low activity Sus scrofa
-
intestine low activity Sus scrofa
-
kidney
-
Sus scrofa
-
kidney low activity Sus scrofa
-
liver
-
Sus scrofa
-
liver high activity Sus scrofa
-
milk
-
Sus scrofa
-
muscle low activity Sus scrofa
-
pancreas
-
Sus scrofa
-
pancreas the piglet pancreatic GAMT activity is only 1% of that found in the liver Sus scrofa
-
skeletal muscle
-
Sus scrofa
-
small intestine
-
Sus scrofa
-
stomach
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00035
-
brain Sus scrofa
0.0007
-
intestine Sus scrofa
0.00084
-
muscle Sus scrofa
0.0019
-
kidney Sus scrofa
0.0058
-
pancreas Sus scrofa
0.0286
-
liver Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + guanidinoacetate
-
Sus scrofa S-adenosyl-L-homocysteine + creatine
-
ir

Synonyms

Synonyms Comment Organism
GAA methyltransferase
-
Sus scrofa
GAMT
-
Sus scrofa
guanidinoacetate methyltransferase
-
Sus scrofa