BRENDA - Enzyme Database
show all sequences of 2.1.1.198

Aminoglycoside resistance 16S rRNA methyltransferases block endogenous methylation, affect translation efficiency and fitness of the host

Lioy, V.S.; Goussard, S.; Guerineau, V.; Yoon, E.J.; Courvalin, P.; Galimand, M.; Grillot-Courvalin, C.; RNA 20, 382-391 (2014)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
Escherichia coli
-
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
-
?
S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
Escherichia coli BW25113
-
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
-
?
S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
Escherichia coli MM294
-
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Escherichia coli
-
-
-
Escherichia coli BW25113
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
-
735241
Escherichia coli
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
-
-
?
S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
-
735241
Escherichia coli BW25113
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
-
-
?
S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
-
735241
Escherichia coli MM294
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
Escherichia coli
-
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
-
?
S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
Escherichia coli BW25113
-
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
-
?
S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
Escherichia coli MM294
-
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
-
735241
Escherichia coli
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
-
-
?
S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
-
735241
Escherichia coli BW25113
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
-
-
?
S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
-
735241
Escherichia coli MM294
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
enzyme deletion affects efficiency of non-AUG initiation and the fidelity of translation
Escherichia coli
General Information (protein specific)
General Information
Commentary
Organism
malfunction
enzyme deletion affects efficiency of non-AUG initiation and the fidelity of translation
Escherichia coli
Other publictions for EC 2.1.1.198
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733030
Zhao
Purification, crystallization ...
Escherichia coli
Acta Crystallogr. Sect. F
70
1256-1259
2014
-
-
1
1
-
-
-
-
-
-
1
1
-
1
-
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1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
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-
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-
1
-
1
-
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-
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-
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735241
Lioy
Aminoglycoside resistance 16S ...
Escherichia coli, Escherichia coli BW25113
RNA
20
382-391
2014
-
-
-
-
-
-
-
-
-
-
-
3
-
28
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
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-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
705980
Kimura
Fine-tuning of the ribosomal d ...
Escherichia coli
Nucleic Acids Res.
38
1341-1352
2010
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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-
-
-
-
-
1
-
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-
-
-
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-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-