Cloned (Comment) | Organism |
---|---|
gene rlmN | Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | Staphylococcus aureus | - |
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
gene rlmN | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | - |
Staphylococcus aureus | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RlmN | - |
Staphylococcus aureus |
General Information | Comment | Organism |
---|---|---|
malfunction | a naturally occurring rlmN mutation, by codon insertion in the rlmN gene, in a clinical Staphylococcus aureus isolate, strain JKD6229, decreases susceptibility to oxazolidinone antibiotic linezolid and is thought to increase the extent of A2503 modification, but mutation in fact abolishes RlmN activity, resulting in a lack of A2503 modification. rlmN knockout mutant Staphylococcus aureus Newman strain, SAV1218, shows a slight decrease in linezolid resistance, overview | Staphylococcus aureus |