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Literature summary for 2.1.1.189 extracted from

  • Shoji, T.; Takaya, A.; Sato, Y.; Kimura, S.; Suzuki, T.; Yamamoto, T.
    RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmAII in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithromycin susceptibility (2015), Nucleic Acids Res., 43, 8964-8972.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptococcus pneumoniae the enzyme also methylates uracil1939 in 23S rRNA ?
-
?
additional information Streptococcus pneumoniae S1 the enzyme also methylates uracil1939 in 23S rRNA ?
-
?
S-adenosyl-L-methionine + uracil747 in 23S rRNA Streptococcus pneumoniae
-
S-adenosyl-L-homocysteine + 5-methyluracil747 in 23S rRNA
-
?
S-adenosyl-L-methionine + uracil747 in 23S rRNA Streptococcus pneumoniae S1
-
S-adenosyl-L-homocysteine + 5-methyluracil747 in 23S rRNA
-
?

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
-
-
-
Streptococcus pneumoniae S1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme also methylates uracil1939 in 23S rRNA Streptococcus pneumoniae ?
-
?
additional information the enzyme also methylates uracil1939 in 23S rRNA Streptococcus pneumoniae S1 ?
-
?
S-adenosyl-L-methionine + uracil747 in 23S rRNA
-
Streptococcus pneumoniae S-adenosyl-L-homocysteine + 5-methyluracil747 in 23S rRNA
-
?
S-adenosyl-L-methionine + uracil747 in 23S rRNA
-
Streptococcus pneumoniae S1 S-adenosyl-L-homocysteine + 5-methyluracil747 in 23S rRNA
-
?

Synonyms

Synonyms Comment Organism
RlmCD
-
Streptococcus pneumoniae
SP 1029
-
Streptococcus pneumoniae

General Information

General Information Comment Organism
malfunction enzyme inactivation reduces N1-methylated level of G748 by RlmAII in vivo, leading to telithromycin resistance when the nucleotide A2058, located in domain V of 23S rRNA, is dimethylated by the dimethyltransferase Erm(B) Streptococcus pneumoniae
metabolism methylation of uridine747 by the enzyme enhances adjacent guanine748 methylation by RlmAII leading to telithromycin-susceptibility Streptococcus pneumoniae