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Literature summary for 2.1.1.187 extracted from
- Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant (1998), J. Bacteriol., 180, 359-365.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + guanine745 in 23S rRNA | Escherichia coli | the methylation at guanine745 is confined to Gram-negative bacteria | S-adenosyl-L-homocysteine + N1-methylguanine745 in 23S rRNA | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P36999 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + guanine745 in 23S rRNA | - |
Escherichia coli | S-adenosyl-L-homocysteine + N1-methylguanine745 in 23S rRNA | - |
? | |
| S-adenosyl-L-methionine + guanine745 in 23S rRNA | the methylation at guanine745 is confined to Gram-negative bacteria | Escherichia coli | S-adenosyl-L-homocysteine + N1-methylguanine745 in 23S rRNA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 23S rRNA m1G745 methyltransferase | - |
Escherichia coli |
| YebH | - |
Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | a mutant deficient in N1-methylguanine745 modification shows a 40% decreased growth rate in rich media, a drastic reduction in loosely coupled ribosomes, a 20% decreased polypeptide chain elongation rate, and increased resistance to the ribosome binding antibiotic viomycin | Escherichia coli |
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