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Literature summary for 2.1.1.187 extracted from

  • Liu, M.; Novotny, G.W.; Douthwaite, S.
    Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase (2004), RNA, 10, 1713-1720.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Acinetobacter sp.

Organism

Organism UniProt Comment Textmining
Acinetobacter sp. Q9AEP4
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Acinetobacter sp.

Synonyms

Synonyms Comment Organism
RlmAI methyltransferase
-
 Acinetobacter sp.

General Information

General Information Comment Organism
malfunction slow growth of the Acinetobacter rlmAI knockout. The growth defect of the Acinetobacter rlmAI knockout is lost during serial passaging of the strain on agar plates. None of the Acinetobacter or Escherichia coli cells tested has regained their ability to methylate G745, and all are thus pseudorevertants. The putative second-site mutations are possibly not rescuing the lack of G745 methylation, but are perhaps compensating for some other function of RlmAI. Cell growth is not dependent on G745 methylation, and the RlmAI methyltransferase therefore has another primary function Acinetobacter sp.