Literature summary for 2.1.1.183 extracted from

O'Farrell, H.C.; Pulicherla, N.; Desai, P.M.; Rife, J.P.
Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution (2006), RNA, 12, 725-733.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	C7GSG6	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4 S-adenosyl-L-methionine + adenine1779/1780 in 18S rRNA	-	Saccharomyces cerevisiae	4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA	-	?
additional information	the enzyme catalyzed methylation of Escherichia coli 30S ribosomes. The enzyme produces a mixture of N6-methyladenine and 6-dimethyladenine (1.4 times as much N6-methyladenine as N6-dimethyladenine). 80% of the potential sites are methylated after 2 h. Under the assay conditions, ScDim1 releases the N6-methyladenine intermediate, which is subsequently converted to the N6-dimethyladenine product after an additional binding event	Saccharomyces cerevisiae	?	-	?

Synonyms

Synonyms	Comment	Organism
ScDim1	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)