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Literature summary for 2.1.1.182 extracted from
- Mechanism of kasugamycin resistance in Escherichia coli (1972), Nat. New Biol., 235, 6-9.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA | Escherichia coli | - |
4 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA | - |
Escherichia coli | 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA | - |
? | |
| 4 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA | 4 methyl groups are incorporated per 16S RNA molecule, both adenine residues in the 16S RNA sequence AACCUG are dimethylated | Escherichia coli | 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA | - |
? | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | strains lacking the methylase are resistant to kasugamycin | Escherichia coli |
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