Literature summary for 2.1.1.180 extracted from

Kanazawa, H.; Baba, F.; Koganei, M.; Kondo, J.
A structural basis for the antibiotic resistance conferred by an N1-methylation of A1408 in 16S rRNA (2017), Nucleic Acids Res., 45, 12529-12535 .

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	A8C927	-	-

General Information

General Information	Comment	Organism
physiological function	NpmA confers resistance to aminoglycosides. Structure of the bacterial ribosomal decoding A site with an A1408m1A antibiotic-resistance mutation both in the presence and absence of aminoglycosides shows that G418 and paromomycin both possessing a 6'-OH group specifically bind to the mutant A site and disturb its function as a molecular switch in the decoding process. Binding of gentamicin with a 6'-NH3+ group to the mutant A site cannot be observed. Adenine 1408 may change ist conformation during the N1-methylation reaction by NpmA	Escherichia coli

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Release 2023.1 (January 2023)