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Literature summary for 2.1.1.179 extracted from
- Aminoglycoside resistance by ArmA-mediated ribosomal 16S methylation in human bacterial pathogens (2006), J. Mol. Biol., 359, 358-364.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + guanine1405 in 16S rRNA | plasmid pAT780 | methylation at guanine1405 mediates cellular resistance by blocking aminoglycoside binding by ribosomes | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| plasmid pAT780 | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
plasmid pAT780 |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + guanine1405 in 16S rRNA | methylation at guanine1405 mediates cellular resistance by blocking aminoglycoside binding by ribosomes | plasmid pAT780 | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + guanine1405 in 16S rRNA | the ArmA methylation reaction is specific for the 30S ribosomal subunit. Neither 16S rRNA alone nor the 70S ribosome is a substrate for this reaction under experimental conditions, implicating ribosomal proteins in substrate recognition | plasmid pAT780 | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ArmA | - |
plasmid pAT780 |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | plasmid pAT780 |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | plasmid pAT780 |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | G1405 methylation produces aminoglycoside resistance by diminishing the affinity of the ribosome for gentamicin | plasmid pAT780 |
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