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Literature summary for 2.1.1.177 extracted from

  • Purta, E.; Kaminska, K.H.; Kasprzak, J.M.; Bujnicki, J.M.; Douthwaite, S.
    YbeA is the m3Psi methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA (2008), RNA, 14, 2234-2244.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.177

Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + pseudouridine1915 in 23S rRNA Escherichia coli
-
 S-adenosyl-L-homocysteine + N3-methylpseudouridine1915 in 23S rRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A8I8
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + pseudouridine1915 in 23S rRNA = S-adenosyl-L-homocysteine + N3-methylpseudouridine1915 in 23S rRNA mechanism: the enzyme docks into the ribosomal A site without encroaching into the P site. YbeA makes extensive interface contacts with both the 30S and 50S subunits to align its active site cofactor adjacent to nucleotide C1915 Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + pseudouridine1915 in 23S rRNA
-
 Escherichia coli S-adenosyl-L-homocysteine + N3-methylpseudouridine1915 in 23S rRNA
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Escherichia coli

Synonyms

Synonyms Comment Organism
m3Psi methyltransferase
-
 Escherichia coli
RlmH
-
 Escherichia coli
rRNA large subunit methyltransferase H
-
 Escherichia coli
YbeA
-
 Escherichia coli

General Information

General Information Comment Organism
malfunction inactivation of the ybeA gene leads to loss of methylation at nucleotide C1915, loss of ybeA function in Escherichia coli causes a slight slowing of the growth rate Escherichia coli
physiological function methylation by YbeA possibly functions as a stamp of approval signifying that the 50S subunit has engaged in translational initiation Escherichia coli