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Literature summary for 2.1.1.170 extracted from

  • Okamoto, S.; Tamaru, A.; Nakajima, C.; Nishimura, K.; Tanaka, Y.; Tokuyama, S.; Suzuki, Y.; Ochi, K.
    Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria (2007), Mol. Microbiol., 63, 1096-1106.
    View publication on PubMed
Search for more literature for 2.1.1.170

Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli

Protein Variants

Protein Variants Comment Organism
additional information mutations within the gene gidB confer low-level streptomycin resistance. gidB mutations emerge spontaneously at a high frequency of 0.000001 and, once emerged, result in vigorous emergence of high-level streptomycin-resistant mutants at a frequency more than 2000 times greater than that seen in wild-type strains Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli BW25113
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + guanine527 in 16S rRNA GidB is a m7G methyltransferase specific for 16S rRNA, identification of methylated nucleotide Escherichia coli S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine527 in 16S rRNA GidB is a m7G methyltransferase specific for 16S rRNA, identification of methylated nucleotide Escherichia coli BW25113 S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA
-
 ?

Synonyms

Synonyms Comment Organism
gidB
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Escherichia coli

General Information

General Information Comment Organism
malfunction mutations within the gene gidB confer low-level streptomycin resistance. gidB Mmutations emerge spontaneously at a high frequency of 0.000001 and, once emerged, result in vigorous emergence of high-level streptomycin-resistant mutants at a frequency more than 2000 times greater than that seen in wild-type strains Escherichia coli