Literature summary for 2.1.1.17 extracted from

Tessitore, L.; Dianzani, I.; Cui, Z.; Vance, D.E.
Diminished expression of phosphatidylethanolamine N-methyltransferase 2 during hepatocarcinogenesis (1999), Biochem. J., 337, 23-27.

No PubMed abstract available

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + phosphatidylethanolamine	Rattus norvegicus	possible role of PEMT2 in the suppression of liver proliferation, and perhaps in hepatic carcinogenesis	S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	normal liver, nodules, advanced nodules and hepatomas. Enzyme form PEMT2 is diminished during liver carcinogenesis	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + phosphatidylethanolamine	-	Rattus norvegicus	S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine	-	?
S-adenosyl-L-methionine + phosphatidylethanolamine	possible role of PEMT2 in the suppression of liver proliferation, and perhaps in hepatic carcinogenesis	Rattus norvegicus	S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine	-	?

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Release 2023.1 (January 2023)