Literature summary for 2.1.1.168 extracted from

Garone, C.; DSouza, A.R.; Dallabona, C.; Lodi, T.; Rebelo-Guiomar, P.; Rorbach, J.; Donati, M.A.; Procopio, E.; Montomoli, M.; Guerrini, R.; Zeviani, M.; Calvo, S.E.; Mootha, V.K.; DiMauro, S.; Ferrero, I.; Minczuk, M.
Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome (2017), Hum. Mol. Genet., 26, 4257-4266 .

Search for more literature for 2.1.1.168

Cloned(Commentary)

Cloned (Comment)	Organism
-	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
G259R	complementation of a knockout strain with mutant G259R gene fails to rescue the respiratory phenotype	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P53123	-	-

Synonyms

Synonyms	Comment	Organism
MRM2	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
physiological function	a knockout mutant shows a defect in respiration and the reduction of the 2'-O-methylmodification at position U2791 in the yeast mitochondrial 21S rRNA. Complementation with the Mrm2 allele carrying the yeast mutation G259R which is equivalent to G189R in the human gene fails to rescue the respiratory phenotype, which is instead completely rescued by expressing the wild-type allele	Saccharomyces cerevisiae

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)