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Literature summary for 2.1.1.14 extracted from

  • Sahu, U.; Rajendra, V.K.H.; Kapnoor, S.S.; Bhagavat, R.; Chandra, N.; Rangarajan, P.N.
    Methionine synthase is localized to the nucleus in Pichia pastoris and Candida albicans and to the cytoplasm in Saccharomyces cerevisiae (2017), J. Biol. Chem., 292, 14730-14746 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
D113R mutation abrogate nuclear localization Komagataella pastoris
R742A nuclear localization is abrogated by the deletion of 107 C-terminal amino acids or the R742A mutation Komagataella pastoris

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus nuclear localization is abrogated by the deletion of 107 C-terminal amino acids or the R742A mutation Komagataella pastoris 5634
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Organism

Organism UniProt Comment Textmining
Komagataella pastoris A0A1B2JIW1
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Subunits

Subunits Comment Organism
More dimer-like configuration in which Arg-742 of a monomer forms a salt bridge with Asp-113 of another monomer, in silico analysis Komagataella pastoris

Synonyms

Synonyms Comment Organism
Met6
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Komagataella pastoris

General Information

General Information Comment Organism
physiological function a strain carrying a deletion of the MET6 gene exhibits methionine as well as adenine auxotrophy. Methionine synthase targeted to the cytoplasm via a heterologous nuclear export signal, is expressed at very low levels and is unable to reverse methionine and adenine auxotrophy of a Met6 deletion strain Komagataella pastoris