BRENDA - Enzyme Database
show all sequences of 2.1.1.14

Sulphur metabolism. F. Enzymes involved in the synthesis of methionine

Madison, J.T.; Methods Plant Biochem. 3, 361-369 (1990)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
methionine
-
Daucus carota
methionine
-
Hordeum vulgare
methionine
-
Phaseolus sp.
methionine
-
Pisum sativum
methionine
-
Spinacia oleracea
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.000026
-
5-methyltetrahydropteroylglutamate
-
Pisum sativum
0.0022
-
S-methylmethionine
-
Pisum sativum
0.004
-
S-adenosylmethionine
-
Pisum sativum
0.041
-
homocysteine
cosubstrate S-methyl-L-methionine
Phaseolus sp.
0.055
-
S-methylmethionine
-
Phaseolus sp.
0.6
-
homocysteine
cosubstrate 5-methyltetrahydropteroylglutamate
Pisum sativum
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
chloroplast
-
Daucus carota
9507
-
chloroplast
-
Hordeum vulgare
9507
-
chloroplast
-
Phaseolus sp.
9507
-
chloroplast
-
Pisum sativum
9507
-
chloroplast
-
Spinacia oleracea
9507
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
stimulates
Daucus carota
Mg2+
stimulates
Hordeum vulgare
Mg2+
stimulates
Phaseolus sp.
Mg2+
stimulates
Pisum sativum
Mg2+
stimulates
Spinacia oleracea
phosphate
-
Daucus carota
phosphate
-
Hordeum vulgare
phosphate
-
Phaseolus sp.
phosphate
-
Pisum sativum
phosphate
-
Spinacia oleracea
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Hordeum vulgare
final step in methionine synthesis
?
-
-
-
additional information
Spinacia oleracea
final step in methionine synthesis
?
-
-
-
additional information
Pisum sativum
final step in methionine synthesis
?
-
-
-
additional information
Daucus carota
final step in methionine synthesis
?
-
-
-
additional information
Phaseolus sp.
final step in methionine synthesis
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Daucus carota
-
carrot
-
Hordeum vulgare
-
barley
-
Phaseolus sp.
-
bean
-
Pisum sativum
-
pea, 2 enzyme forms: a 5-methyltetrahydropteroylglutamate dependent enzyme and a S-methylmethionine dependent enzyme
-
Spinacia oleracea
-
spinach
-
Purification (Commentary)
Commentary
Organism
-
Phaseolus sp.
Reaction
Reaction
Commentary
Organism
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine
final step in methionine synthesis
Daucus carota
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine
final step in methionine synthesis
Hordeum vulgare
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine
final step in methionine synthesis
Phaseolus sp.
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine
final step in methionine synthesis
Pisum sativum
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine
final step in methionine synthesis
Spinacia oleracea
Source Tissue
Source Tissue
Commentary
Organism
Textmining
root
-
Daucus carota
-
root
-
Hordeum vulgare
-
root
-
Phaseolus sp.
-
root
-
Pisum sativum
-
root
-
Spinacia oleracea
-
seedling
-
Daucus carota
-
seedling
-
Hordeum vulgare
-
seedling
-
Phaseolus sp.
-
seedling
-
Pisum sativum
-
seedling
-
Spinacia oleracea
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine
-
441322
Hordeum vulgare
tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine
-
441322
Hordeum vulgare
?
5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine
-
441322
Spinacia oleracea
tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine
-
441322
Spinacia oleracea
?
5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine
-
441322
Pisum sativum
tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine
-
441322
Pisum sativum
?
5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine
-
441322
Daucus carota
tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine
-
441322
Daucus carota
?
5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine
-
441322
Phaseolus sp.
tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine
-
441322
Phaseolus sp.
?
additional information
enzymes of higher plants can use the monoglutamate
441322
Hordeum vulgare
?
-
-
-
-
additional information
enzymes of higher plants can use the monoglutamate
441322
Spinacia oleracea
?
-
-
-
-
additional information
enzymes of higher plants can use the monoglutamate
441322
Pisum sativum
?
-
-
-
-
additional information
enzymes of higher plants can use the monoglutamate
441322
Daucus carota
?
-
-
-
-
additional information
enzymes of higher plants can use the monoglutamate
441322
Phaseolus sp.
?
-
-
-
-
additional information
most active with the polyglutamate forms of N5-methyltetrahydropteroylglutamate
441322
Hordeum vulgare
?
-
-
-
-
additional information
most active with the polyglutamate forms of N5-methyltetrahydropteroylglutamate
441322
Spinacia oleracea
?
-
-
-
-
additional information
most active with the polyglutamate forms of N5-methyltetrahydropteroylglutamate
441322
Pisum sativum
?
-
-
-
-
additional information
most active with the polyglutamate forms of N5-methyltetrahydropteroylglutamate
441322
Daucus carota
?
-
-
-
-
additional information
most active with the polyglutamate forms of N5-methyltetrahydropteroylglutamate
441322
Phaseolus sp.
?
-
-
-
-
additional information
final step in methionine synthesis
441322
Hordeum vulgare
?
-
-
-
-
additional information
final step in methionine synthesis
441322
Spinacia oleracea
?
-
-
-
-
additional information
final step in methionine synthesis
441322
Pisum sativum
?
-
-
-
-
additional information
final step in methionine synthesis
441322
Daucus carota
?
-
-
-
-
additional information
final step in methionine synthesis
441322
Phaseolus sp.
?
-
-
-
-
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
441322
Pisum sativum
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
S-adenosylmethionine + homocysteine
-
441322
Pisum sativum
methionine + S-adenosylhomocysteine
-
441322
Pisum sativum
?
S-methylmethionine + homocysteine
-
441322
Pisum sativum
methionine
-
441322
Pisum sativum
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.5
-
5-methyltetrahydropteroylglutamate
Pisum sativum
7.3
-
L-methionine
Pisum sativum
7.9
-
L-methionine
Phaseolus sp.
Cofactor
Cofactor
Commentary
Organism
Structure
additional information
no requirement for a reducing system; no requirement for S-adenosylmethionine; vitamin-B12 independent enzyme
Daucus carota
additional information
no requirement for a reducing system; no requirement for S-adenosylmethionine; vitamin-B12 independent enzyme
Hordeum vulgare
additional information
no requirement for a reducing system; no requirement for S-adenosylmethionine; vitamin-B12 independent enzyme
Phaseolus sp.
additional information
no requirement for a reducing system; no requirement for S-adenosylmethionine; vitamin-B12 independent enzyme
Pisum sativum
additional information
no requirement for a reducing system; no requirement for S-adenosylmethionine; vitamin-B12 independent enzyme
Spinacia oleracea
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
additional information
no requirement for a reducing system; no requirement for S-adenosylmethionine; vitamin-B12 independent enzyme
Daucus carota
additional information
no requirement for a reducing system; no requirement for S-adenosylmethionine; vitamin-B12 independent enzyme
Hordeum vulgare
additional information
no requirement for a reducing system; no requirement for S-adenosylmethionine; vitamin-B12 independent enzyme
Phaseolus sp.
additional information
no requirement for a reducing system; no requirement for S-adenosylmethionine; vitamin-B12 independent enzyme
Pisum sativum
additional information
no requirement for a reducing system; no requirement for S-adenosylmethionine; vitamin-B12 independent enzyme
Spinacia oleracea
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
methionine
-
Daucus carota
methionine
-
Hordeum vulgare
methionine
-
Phaseolus sp.
methionine
-
Pisum sativum
methionine
-
Spinacia oleracea
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.000026
-
5-methyltetrahydropteroylglutamate
-
Pisum sativum
0.0022
-
S-methylmethionine
-
Pisum sativum
0.004
-
S-adenosylmethionine
-
Pisum sativum
0.041
-
homocysteine
cosubstrate S-methyl-L-methionine
Phaseolus sp.
0.055
-
S-methylmethionine
-
Phaseolus sp.
0.6
-
homocysteine
cosubstrate 5-methyltetrahydropteroylglutamate
Pisum sativum
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
chloroplast
-
Daucus carota
9507
-
chloroplast
-
Hordeum vulgare
9507
-
chloroplast
-
Phaseolus sp.
9507
-
chloroplast
-
Pisum sativum
9507
-
chloroplast
-
Spinacia oleracea
9507
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
stimulates
Daucus carota
Mg2+
stimulates
Hordeum vulgare
Mg2+
stimulates
Phaseolus sp.
Mg2+
stimulates
Pisum sativum
Mg2+
stimulates
Spinacia oleracea
phosphate
-
Daucus carota
phosphate
-
Hordeum vulgare
phosphate
-
Phaseolus sp.
phosphate
-
Pisum sativum
phosphate
-
Spinacia oleracea
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Hordeum vulgare
final step in methionine synthesis
?
-
-
-
additional information
Spinacia oleracea
final step in methionine synthesis
?
-
-
-
additional information
Pisum sativum
final step in methionine synthesis
?
-
-
-
additional information
Daucus carota
final step in methionine synthesis
?
-
-
-
additional information
Phaseolus sp.
final step in methionine synthesis
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
-
Phaseolus sp.
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
root
-
Daucus carota
-
root
-
Hordeum vulgare
-
root
-
Phaseolus sp.
-
root
-
Pisum sativum
-
root
-
Spinacia oleracea
-
seedling
-
Daucus carota
-
seedling
-
Hordeum vulgare
-
seedling
-
Phaseolus sp.
-
seedling
-
Pisum sativum
-
seedling
-
Spinacia oleracea
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine
-
441322
Hordeum vulgare
tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine
-
441322
Hordeum vulgare
?
5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine
-
441322
Spinacia oleracea
tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine
-
441322
Spinacia oleracea
?
5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine
-
441322
Pisum sativum
tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine
-
441322
Pisum sativum
?
5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine
-
441322
Daucus carota
tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine
-
441322
Daucus carota
?
5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine
-
441322
Phaseolus sp.
tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine
-
441322
Phaseolus sp.
?
additional information
enzymes of higher plants can use the monoglutamate
441322
Hordeum vulgare
?
-
-
-
-
additional information
enzymes of higher plants can use the monoglutamate
441322
Spinacia oleracea
?
-
-
-
-
additional information
enzymes of higher plants can use the monoglutamate
441322
Pisum sativum
?
-
-
-
-
additional information
enzymes of higher plants can use the monoglutamate
441322
Daucus carota
?
-
-
-
-
additional information
enzymes of higher plants can use the monoglutamate
441322
Phaseolus sp.
?
-
-
-
-
additional information
most active with the polyglutamate forms of N5-methyltetrahydropteroylglutamate
441322
Hordeum vulgare
?
-
-
-
-
additional information
most active with the polyglutamate forms of N5-methyltetrahydropteroylglutamate
441322
Spinacia oleracea
?
-
-
-
-
additional information
most active with the polyglutamate forms of N5-methyltetrahydropteroylglutamate
441322
Pisum sativum
?
-
-
-
-
additional information
most active with the polyglutamate forms of N5-methyltetrahydropteroylglutamate
441322
Daucus carota
?
-
-
-
-
additional information
most active with the polyglutamate forms of N5-methyltetrahydropteroylglutamate
441322
Phaseolus sp.
?
-
-
-
-
additional information
final step in methionine synthesis
441322
Hordeum vulgare
?
-
-
-
-
additional information
final step in methionine synthesis
441322
Spinacia oleracea
?
-
-
-
-
additional information
final step in methionine synthesis
441322
Pisum sativum
?
-
-
-
-
additional information
final step in methionine synthesis
441322
Daucus carota
?
-
-
-
-
additional information
final step in methionine synthesis
441322
Phaseolus sp.
?
-
-
-
-
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
441322
Pisum sativum
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
S-adenosylmethionine + homocysteine
-
441322
Pisum sativum
methionine + S-adenosylhomocysteine
-
441322
Pisum sativum
?
S-methylmethionine + homocysteine
-
441322
Pisum sativum
methionine
-
441322
Pisum sativum
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.5
-
5-methyltetrahydropteroylglutamate
Pisum sativum
7.3
-
L-methionine
Pisum sativum
7.9
-
L-methionine
Phaseolus sp.
Other publictions for EC 2.1.1.14
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733198
Yang
Proteomic insights into metabo ...
Saccharopolyspora spinosa
Appl. Microbiol. Biotechnol.
99
8629-8641
2015
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734490
Ubhi
The cobalamin-independent meth ...
Candida albicans, Candida albicans ATCC MYA-2876
J. Mol. Biol.
427
901-909
2015
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735002
Saint-Macary
Methionine biosynthesis is ess ...
Magnaporthe oryzae
PLoS ONE
10
e0111108
2015
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733170
Mordukhova
Evolved cobalamin-independent ...
Escherichia coli
Appl. Environ. Microbiol.
79
7905-7915
2013
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1
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2
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3
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720398
Fujiwara
Mechanism of methionine syntha ...
Escherichia coli
Microbiology
158
917-924
2012
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720259
Fu
Crystal structures of cobalami ...
Streptococcus mutans
J. Mol. Biol.
412
688-697
2011
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Gonzalez
Comparison of cobalamin-indepe ...
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441326
Taylor
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N5-Methyltetrahydrofolate-homo ...
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