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Literature summary for 2.1.1.139 extracted from

  • Weidner, S.; Kittelmann, M.; Goeke, K.; Ghisalba, O.; Zähner, H.
    3'-Demethoxy-3'hydroxystaurosporine O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine (1998), J. Antibiot., 51, 697-682.
No PubMed abstract available
Search for more literature for 2.1.1.139

Activating Compound

Activating Compound Comment Organism Structure
tryptophan 2fold increase at 0.2 mM Streptomyces longisporoflavus

Inhibitors

Inhibitors Comment Organism Structure
1H-indole 62% activity left at 1.1 mM Streptomyces longisporoflavus
3'-demethylstaurosporine 69% activity at 1.1 mM Streptomyces longisporoflavus
anthranilate 75% activity left at 1.1 mM Streptomyces longisporoflavus
Indole-3-pyruvate 44% activity left at 1.1 mM Streptomyces longisporoflavus
S-(5'-adenosyl)-L-homocysteine strong inhibition, 8% activity left at 1.1 mM, probably competitive inhibition Streptomyces longisporoflavus
tryptophan 64% activity left at 1.1 mM Streptomyces longisporoflavus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + 3'-demethylstaurosporine Streptomyces longisporoflavus
-
 S-adenosyl-L-homocysteine + staurosporine
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces longisporoflavus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
anion exchange chromatography, partial purification Streptomyces longisporoflavus

Storage Stability

Storage Stability Organism
4°C, 6 days, 80% Streptomyces longisporoflavus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 3'-demethylstaurosporine
-
 Streptomyces longisporoflavus S-adenosyl-L-homocysteine + staurosporine
-
 ?