Literature summary for 2.1.1.137 extracted from

Zhang, H.; Ge, Y.; He, P.; Chen, X.; Carina, A.; Qiu, Y.; Aga, D.S.; Ren, X.
Interactive effects of N6AMT1 and As3MT in arsenic biomethylation (2015), Toxicol. Sci., 146, 354-362 .

Search for more literature for 2.1.1.137

Cloned(Commentary)

Cloned (Comment)	Organism
expression in UROtsa cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9HBK9	-	-
Homo sapiens	Q9Y5N5	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	moderate expression	Homo sapiens	-
kidney	weak expression	Homo sapiens	-
liver	strong expression	Homo sapiens	-
liver	weak to moderate expression	Homo sapiens	-
additional information	the As3MT protein level is lower in cancer tissues in comparison to normal tissues	Homo sapiens	-
additional information	the level of N6AMT1 protein in most cancer tissues is comparable to the levels in normal tissues	Homo sapiens	-
prostate gland	moderate expression	Homo sapiens	-
prostate gland	weak expression	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + methylarsonate	-	Homo sapiens	S-adenosyl-L-homocysteine + dimethylarsinous acid	-	?

Synonyms

Synonyms	Comment	Organism
AS3MT	-	Homo sapiens
N6AMT1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	N6AMT1 converts monomethylarsonous acid(III) into the less toxic dimethylarsonic acid (V). The effects of N6AMT1 in arsenic metabolism are relatively minor and limited when compared with the action of As3MT	Homo sapiens

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Release 2023.1 (January 2023)