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Literature summary for 2.1.1.137 extracted from

  • Li, X.; Geng, Z.; Chang, J.; Song, X.; Wang, Z.
    Mutational analysis of residues in human arsenic (III) methyltransferase (hAS3MT) belonging to 5 A around S-adenosylmethionine (SAM) (2014), Biochimie, 107 Pt B, 396-405.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
G134A the mutant’s activity is seriously impaired compared with that of wild type Homo sapiens
G60A inactive Homo sapiens
G80A inactive Homo sapiens
G82A the mutant’s activity is seriously impaired compared with that of wild type Homo sapiens
I101A inactive Homo sapiens
L160A inactive Homo sapiens
L77A the mutant’s activity is seriously impaired compared with that of wild type Homo sapiens
N155A inactive Homo sapiens
R57A the mutant's activity is seriously impaired compared with that of wild type Homo sapiens
R83A the mutant’s activity is seriously impaired compared with that of wild type Homo sapiens
S81A the mutant’s activity is seriously impaired compared with that of wild type Homo sapiens
T104A the mutant’s activity is seriously impaired compared with that of wild type Homo sapiens
V157A the mutant’s activity is seriously impaired compared with that of wild type Homo sapiens
V161A the mutant’s activity is seriously impaired compared with that of wild type Homo sapiens
Y135A the mutant’s activity is seriously impaired compared with that of wild type Homo sapiens
Y58A the mutant’s activity is seriously impaired compared with that of wild type Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0012
-
arsenite mutant enzyme G134A, at pH 7.0 and 37°C Homo sapiens
0.0018
-
arsenite mutant enzyme R83A, at pH 7.0 and 37°C Homo sapiens
0.0022
-
arsenite mutant enzyme V157A, at pH 7.0 and 37°C Homo sapiens
0.0026
-
arsenite mutant enzyme R57A, at pH 7.0 and 37°C Homo sapiens
0.0027
-
arsenite mutant enzyme S81A, at pH 7.0 and 37°C Homo sapiens
0.0032
-
arsenite wild type enzyme, at pH 7.0 and 37°C Homo sapiens
0.0032
-
arsenite mutant enzyme V161A, at pH 7.0 and 37°C Homo sapiens
0.007
-
arsenite mutant enzyme T104A, at pH 7.0 and 37°C Homo sapiens
0.007
-
arsenite mutant enzyme Y135A, at pH 7.0 and 37°C Homo sapiens
0.0076
-
arsenite mutant enzyme Y58A, at pH 7.0 and 37°C Homo sapiens
0.0087
-
arsenite mutant enzyme G82A, at pH 7.0 and 37°C Homo sapiens
0.0096
-
arsenite mutant enzyme L77A, at pH 7.0 and 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + arsenite Homo sapiens
-
S-adenosyl-L-homocysteine + methylarsonate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HBK9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + arsenite
-
Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
-
?

Synonyms

Synonyms Comment Organism
arsenic (III) methyltransferase
-
Homo sapiens
AS3MT
-
Homo sapiens