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Literature summary for 2.1.1.137 extracted from

  • Wood, T.C.; Salavagionne, O.E.; Mukherjee, B.; Wang, L.; Klumpp, A.F.; Thomae, B.A.; Eckloff, B.W.; Schaid, D.J.; Wieben, E.D.; Weinshilboum, R.M.
    Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies (2006), J. Biol. Chem., 281, 7364-7373.
    View publication on PubMed
Search for more literature for 2.1.1.137

Cloned(Commentary)

Cloned (Comment) Organism
after expression in COS-1 cells and correction for transfection efficiency, the Trp173 allozyme displays 31%, Thr287 350%, Ile306 4.8%, and Thr287/Ile306 6.2% of the activity of the wild type allozyme, with 20, 190, 4.4, and 7.9% of the level of wild-type immunoreactive protein, respectively Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0031
-
 S-adenosyl-L-methionine 37°C, pH 8.0, Trp173 allozyme Homo sapiens
0.0045
-
 arsenite 37°C, pH 8.0, Thr287 allozyme Homo sapiens
0.0046
-
 S-adenosyl-L-methionine 37°C, pH 8.0, wild-type enzyme Homo sapiens
0.0089
-
 arsenite 37°C, pH 8.0, Trp173 allozyme Homo sapiens
0.011
-
 S-adenosyl-L-methionine 37°C, pH 8.0, Thr287 allozyme Homo sapiens
0.0118
-
 arsenite 37°C, pH 8.0, wild-type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + arsenite Homo sapiens AS3MT may contribute to variation in arsenic metabolism and, perhaps, arsenic-dependent carcinogenesis in humans S-adenosyl-L-homocysteine + methylarsonate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + arsenite
-
 Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
-
 ?
S-adenosyl-L-methionine + arsenite AS3MT may contribute to variation in arsenic metabolism and, perhaps, arsenic-dependent carcinogenesis in humans Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
-
 ?

Synonyms

Synonyms Comment Organism
AS3MT
-
 Homo sapiens