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Literature summary for 2.1.1.137 extracted from

  • Drobna, Z.; Xing, W.; Thomas, D.J.; Styblo, M.
    shRNA silencing of AS3MT expression minimizes arsenic methylation capacity of HepG2 cells (2006), Chem. Res. Toxicol., 19, 894-898.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + arsenite Homo sapiens hAS3MT is the key enzyme in the pathway for methylation of iAs in human hepatic cells S-adenosyl-L-homocysteine + methylarsonate
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell in a stable clonal HepG2/A cell line, AS3MT mRNA and protein levels are reduced by 83 and 88%, respectively. The capacity to methylate inorganic arsenic decreases by 70% Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + arsenite
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Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
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?
S-adenosyl-L-methionine + arsenite hAS3MT is the key enzyme in the pathway for methylation of iAs in human hepatic cells Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
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?

Synonyms

Synonyms Comment Organism
arsenic (+3 oxidation state) methyltransferase
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Homo sapiens
hAS3MT
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Homo sapiens