Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + arsenite | Homo sapiens | hAS3MT is the key enzyme in the pathway for methylation of iAs in human hepatic cells | S-adenosyl-L-homocysteine + methylarsonate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | in a stable clonal HepG2/A cell line, AS3MT mRNA and protein levels are reduced by 83 and 88%, respectively. The capacity to methylate inorganic arsenic decreases by 70% | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + arsenite | - |
Homo sapiens | S-adenosyl-L-homocysteine + methylarsonate | - |
? | |
S-adenosyl-L-methionine + arsenite | hAS3MT is the key enzyme in the pathway for methylation of iAs in human hepatic cells | Homo sapiens | S-adenosyl-L-homocysteine + methylarsonate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
arsenic (+3 oxidation state) methyltransferase | - |
Homo sapiens |
hAS3MT | - |
Homo sapiens |