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Literature summary for 2.1.1.137 extracted from
- Enzymatic methylation of arsenic compoundes. The marmoset and tamarin, but not the rhesus monkeys are deficient in methyltransferases that methylate inorganic compounds (1996), Toxicol. Appl. Pharmacol., 140, 77-84.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.006 | - |
arsenite | - |
Oryctolagus cuniculus |  |
| 0.006 | - |
arsenite | - |
Macaca mulatta | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Oryctolagus cuniculus | 5829 | - |
| cytosol | - |
Macaca mulatta | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + arsenite | Oryctolagus cuniculus | - |
S-adenosyl-L-homocysteine + methylarsonate | - |
? | |
| S-adenosyl-L-methionine + arsenite | Macaca mulatta | - |
S-adenosyl-L-homocysteine + methylarsonate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Macaca mulatta | - |
rhesus monkey | - |
| no activity in Callithrix jacchus | - |
marmoset monkey | - |
| no activity in Saguinus oedipus | - |
tamarin monkeys | - |
| Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| DEAE-cellulose, Sephadex G-200, Sephadex G-100, anion exchange chromatographie | Macaca mulatta |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Macaca mulatta | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00000128 | - |
- |
Macaca mulatta |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + arsenite | - |
Oryctolagus cuniculus | S-adenosyl-L-homocysteine + methylarsonate | - |
? | |
| S-adenosyl-L-methionine + arsenite | - |
Macaca mulatta | S-adenosyl-L-homocysteine + methylarsonate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
little activity at pH 7.0 | Macaca mulatta |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| S-adenosyl-L-methionine | - |
Oryctolagus cuniculus | |
| S-adenosyl-L-methionine | - |
Macaca mulatta | |
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Release 2023.1 (January 2023)
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