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Literature summary for 2.1.1.13 extracted from

  • Guest, J.R.; Friedman, S.; Foster, M.A.; Tejerina, G.; Woods, D.D.
    Transfer of the methyl group from N5-methyltetrahydrofolates to homocysteine in Escherichia coli (1964), Biochem. J., 92, 497-504.
    View publication on PubMedView publication on EuropePMC
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Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 B
-
Escherichia coli B / ATCC 11303
-
 B
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information S-adenosylhomocysteine replaces homocysteine as methyl acceptor to a limited extent Escherichia coli ?
-
 ?
additional information S-adenosylhomocysteine replaces homocysteine as methyl acceptor to a limited extent Escherichia coli B / ATCC 11303 ?
-
 ?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
 Escherichia coli tetrahydropteroylmonoglutamate + L-methionine
-
 ?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
 Escherichia coli B / ATCC 11303 tetrahydropteroylmonoglutamate + L-methionine
-
 ?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
 Escherichia coli tetrahydropteroyltriglutamate + L-methionine
-
 ?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
 Escherichia coli B / ATCC 11303 tetrahydropteroyltriglutamate + L-methionine
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP required Escherichia coli
additional information enzyme requires another protein fraction, ATP, Mg2+, FAD and a NADH-generating system Escherichia coli
vitamin B12 enzyme contains a derivative of vitamin B12 as prosthetic group Escherichia coli