Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.116 extracted from

  • Frenzel, T.; Zenk, M.H.
    S-Adenosyl-L-methionine: 3'-hydroxy-N-methyl-(S)-coclaurine-4'-O-methyl transferase, a regio- and stereoselective enzyme of the (S)-reticuline pathway (1990), Phytochemistry, 29, 3505-3511.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
(R)-3'-Hydroxy-coclaurine
-
Berberis koetineana
(S)-3'-hydroxy-coclaurine
-
Berberis koetineana
(S)-norreticuline
-
Berberis koetineana
(S)-reticuline
-
Berberis koetineana
3'-Hydroxy-N-methyl-(R)-coclaurine
-
Berberis koetineana
Berberine
-
Berberis koetineana
Jatrorrhizine
-
Berberis koetineana

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0045
-
3'-hydroxy-N-methyl-(S)-coclaurine
-
Berberis koetineana
0.03
-
S-adenosyl-L-methionine
-
Berberis koetineana

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
1 * 40000, SDS-PAGE Berberis koetineana
51000
-
gel filtration Berberis koetineana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine Berberis koetineana the enzyme catalyzes the last step in (S)-reticuline biosynthesis ?
-
?

Organism

Organism UniProt Comment Textmining
Berberis koetineana
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Berberis koetineana

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Berberis koetineana
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Berberis koetineana

Storage Stability

Storage Stability Organism
-20°C, 20% glycerol, stable for more than 1 year Berberis koetineana

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-Adenosyl-L-methionine + (R,S)-7-O-methyllaudanosoline 93% of the activity relative to 3'-hydroxy-N-methyl-(S)-coclaurine Berberis koetineana S-Adenosyl-L-homocysteine + norprotosinomenine
-
?
S-Adenosyl-L-methionine + (R,S)-laudanosoline 84% of the activity relative to 3'-hydroxy-N-methyl-(S)-coclaurine Berberis koetineana S-Adenosyl-L-homocysteine + 4'-O-methyllaudanosoline
-
?
S-Adenosyl-L-methionine + (S)-3'-hydroxy-coclaurine 10% of the activity relative to 3'-hydroxy-N-methyl-(S)-coclaurine Berberis koetineana S-Adenosyl-L-homocysteine + (S)-norreticuline
-
?
S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine
-
Berberis koetineana S-Adenosyl-L-homocysteine + (S)-reticuline
-
?
S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine the enzyme catalyzes the last step in (S)-reticuline biosynthesis Berberis koetineana ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 40000, SDS-PAGE Berberis koetineana

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35 40
-
Berberis koetineana

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
6
-
half-life: 15 days Berberis koetineana
20
-
half-life: 3 days Berberis koetineana

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3 8.5
-
Berberis koetineana

pH Range

pH Minimum pH Maximum Comment Organism
7 9 about 50% of maximal activity at pH 7 and at pH 9 Berberis koetineana